{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:22:51Z","timestamp":1745468571960,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"abstract":"<jats:p>Introduction: Nail clubbing is defined as distal phalanx thickening resulting in a bulbous appearance of the digit. We aimed to describe non-pulmonary medical conditions associated with nail clubbing using a cross-sectional approach. Methods: We conducted a cross-sectional analysis of the All of Us Research Program, identifying nail clubbing patients by ICD-10-CM and\/or SNOMED code. Nail clubbing patients with pulmonary disease (cases) were compared to nail clubbing patients without pulmonary disease (controls). Fisher\u2019s exact test\/Pearson\u2019s \u03c72 test analyzed categorical variables. Independent two-sample t tests analyzed continuous variables. Odds ratios (ORs) were analyzed with multivariate logistic regression adjusted for sociodemographic characteristics. Results: In total, 85 participants had nail clubbing, of which 63.53% had a pulmonary disease versus 36.47% of controls. Overall, across both cases and controls, 22% of patients had chronic liver disease, 17% hypothyroidism, 8% HIV infection, and 5% Graves\u2019 disease\/hyperthyroidism. Male versus female patients with nail clubbing had decreased odds of having concurrent respiratory disease diagnosis (OR, 0.37; 95% CI, 0.14\u20130.92, p = 0.03). Conclusion: Greater than one-third of patients had nail clubbing associated with a non-pulmonary systemic disease, and a significant proportion were male. Consideration of a broad differential of pathologies associated with nail clubbing is needed to initiate workup and make appropriate screening referrals. <\/jats:p>","DOI":"10.1159\/000542382","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:02:10Z","timestamp":1730826130000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease \u2013 an All of Us Study"],"prefix":"10.1159","author":[{"given":"Noelle","family":"Desir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari R.","family":"Lipner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20623"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10193"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101507"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130823"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24231"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6194.825"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.3.203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(58)91238-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1235040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2019.03.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4158\/ACCR-2018-0591"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001830"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s1665-2681(19)31926-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1167890"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000542382\/4306556\/000542382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000542382\/4306556\/000542382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:59:23Z","timestamp":1745420363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":15,"URL":"https:\/\/doi.org\/10.1159\/000542382","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"type":"print","value":"2296-9195"},{"type":"electronic","value":"2296-9160"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}