{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:51:43Z","timestamp":1790833903486,"version":"4.1.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>Introduction: Children with idiopathic short stature (ISS) are known to have varying responses to growth hormone (GH) treatment (GHT). Methods: We conducted a post hoc analysis to identify clinical characteristics predictive of good and poor response during year 1 of GHT. Data from the NordiNet\u00ae IOS (NCT00960128) and the ANSWER Program (NCT01009905) were used. Patients were grouped according to their response to GHT; good, middle, and poor responders had a change in HSDS of &gt;1.0, 0.4\u20131.0, and &lt;0.4, respectively. Patients were also grouped according to their responsiveness to GH dose. Logistic regression modelling was performed to identify clinical characteristics predictive of response to GHT. Results: The response analysis set included 207 patients. Patients were 3\u201311 years old (males) or 3\u201310 years old (females) at the start of treatment and were prepubertal throughout year 1 of treatment. Age at the start of treatment (odds ratio [OR] 0.69, 95% confidence interval [CI] 0.5; 0.9, p = 0.0169) and distance from target HSDS (OR: 2.05, 95% CI: 1.1; 3.9, p = 0.0259) were found to be significant independent predictors of being in the good- versus poor-response groups. When patients were grouped according to their responsiveness to GH dose, a positive correlation between GH dose and change in HSDS was observed. Conclusion: We identified younger age and further distance from target HSDS as clinical predictors of response to GHT in a heterogenous population of children with ISS. Future studies, designed to identify the genetic determinants of response to GHT, could further facilitate individualisation of GHT.<\/jats:p>","DOI":"10.1159\/000542579","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:00:45Z","timestamp":1732190445000},"page":"448-460","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Predictors of Good\/Poor Response to Growth Hormone Treatment in Children with Idiopathic Short Stature"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-0262","authenticated-orcid":false,"given":"Andrew","family":"Dauber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-5612","authenticated-orcid":false,"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Ferran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Kelepouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Nedjatian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Helene","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-7360","authenticated-orcid":false,"given":"Alexander Augusto","family":"de Lima Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0509"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60604-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000347121"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200010000-00010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S42602"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10728-020-00390-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00775"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1581"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7157"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031457"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000098707"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-22-0449"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4008\/jcrpe.v1i3.53"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000381642"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000185025"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0707"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000330143"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199810000-00016"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/doi\/10.1159\/000542579\/4303257\/000542579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000542579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:01:43Z","timestamp":1776441703000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,17]]},"published-print":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000542579","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}