{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:49:41Z","timestamp":1791931781494,"version":"4.3.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Erroneous penicillin allergy labels are associated with significant health and economic costs. This study aimed to determine whether deep learning-facilitated proactive consultation to facilitate delabelling may further enhance inpatient penicillin allergy delabelling. Methods: This prospective implementation study utilised a deep learning-guided proactive consultation service, which utilised an inpatient penicillin allergy delabelling protocol. The intervention group comprised all admitted inpatients with a penicillin allergy over the course of a 14-week period in a tertiary hospital. The rate of penicillin allergy delabelling in the intervention group was compared to that of a historical control group. Results: There were 439 patients included in the study, of whom 121 were identified by the algorithm as suitable for penicillin allergy interrogation. Of those identified by the algorithm, 16.5% were successfully delabelled in the inpatient setting within the same admission and 9.9% were referred for outpatient testing. This result was statistically significantly greater compared to the rate of delabelling in the historical control group (0%, p = 0.00001). There were no adverse reactions. The projected annual savings associated with the program over a 12-month period were AUD 1,170,617.16. Conclusion: Deep learning-facilitated proactive inpatient penicillin allergy delabelling was effective, safe, and economical in this single-centre implementation study. Further studies should seek to examine this approach in diverse centres.<\/jats:p>","DOI":"10.1159\/000542589","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:01:00Z","timestamp":1737115260000},"page":"716-723","source":"Crossref","is-referenced-by-count":2,"title":["Proactive Deep Learning-Facilitated Inpatient Penicillin Allergy Delabelling: An Implementation Study"],"prefix":"10.1159","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-6573","authenticated-orcid":false,"given":"Melinda","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Inglis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Thompkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Yuson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Shakib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-998X","authenticated-orcid":false,"given":"William B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.12.023"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/all.15849"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.07.048"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.11.026"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15532"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/imj.43_13197"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tacc.2021.02.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000526424"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16266"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2021.104611"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix794"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3414\/me17-01-0024"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.047"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2023.2173724"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510200062033"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13558"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/iaa\/article-pdf\/doi\/10.1159\/000542589\/4324860\/000542589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000542589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:06:13Z","timestamp":1754409973000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000542589","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28193273","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]}}}