{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:08:52Z","timestamp":1776474532375,"version":"3.51.2"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"abstract":"<jats:p>&lt;p&gt;Introduction: Off-label low-dose oral minoxidil (LDOM) is used for androgenetic alopecia (AGA) treatment, with limited safety data. We investigated LDOM adverse effects (AEs) in AGA patients. Methods: AGA patients taking LDOM were identified (January 1, 2010\u2013December 3, 2022). AEs and management were recorded from follow-up and emergency room visits. Fisher\u2019s exact test, logistic regression, and Benjamini-Hochberg procedure assessed significance and adjusted for multiple comparisons. Results: Three hundred ten AGA patients were analyzed with mean age 47.5 years and 53.2% females. The average LDOM dose was lower for females vs. males. AEs were observed in 14.9% of patients, with dizziness\/lightheadedness, hypertrichosis, and extremity edema being most common. Higher doses were associated with increased likelihood of dizziness\/lightheadedness. Females had higher overall incidence of AEs; however, gender differences did not persist after subgroup analysis. Among patients experiencing AEs, 11.1% adjusted their dosage and 28.9% discontinued treatment. Conclusion: A higher LDOM dose increased risk of dizziness\/lightheadedness in both genders, with females more likely to experience any AE. Patients are often started at inappropriately high doses, causing AE-induced regimen changes. Therefore, we recommend a cautious approach when prescribing LDOM, starting with lower doses and gradually increasing as tolerated, and counseling female patients regarding their higher risk of AEs. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000542630","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T12:00:57Z","timestamp":1732536057000},"page":"227-231","source":"Crossref","is-referenced-by-count":5,"title":["Gender Differences in Adverse Effects and Dosing Practices of Low-Dose Oral Minoxidil for Androgenetic Alopecia: A Retrospective Analysis of 310 Patients"],"prefix":"10.1159","volume":"11","author":[{"given":"Michael M.","family":"Ong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huongly","family":"Do","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-9304","authenticated-orcid":false,"given":"Shari R.","family":"Lipner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000531890"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000525137"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.02.054"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.11.035"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14106"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.054"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13838"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.084"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.010"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000542630\/4313380\/000542630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000542630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:05:16Z","timestamp":1758297916000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,4]]},"published-print":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000542630","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]}}}