{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:20:36Z","timestamp":1788438036525,"version":"build-2803163510"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Background: Microscopic perineural invasion (mPNI) is a histopathological characteristic that can be found in cutaneous squamous cell carcinoma (cSCC). In the eighth edition of the American Joint Committee on Cancer (AJCC), mPNI defined as the involvement of nerves \u22650.1 mm and nerves deeper than the dermis is included in risk stratification of cSCC. The question remains whether other mPNI features are important for optimal cSCC staging. We aimed to summarize the evidence from published studies on the independent association between various mPNI features and the risk of recurrence, metastasis and disease-specific death in patients with cSCC. Summary: Embase, PubMed, and Web of Science were searched from January 2023 to February 2024 to identify studies that reported the prognostic impact of mPNI features in patients \u226518 years with histopathologically verified cSCC. Data on study and tumour characteristics were extracted. Nineteen studies met the inclusion criteria and evaluated one or more mPNI features in cSCC including nerve diameter, the extent of mPNI, the number of affected nerves, and depth of mPNI. Two studies provided evidence that \u201cmPNI \u22650.1 mm\u201d and \u201cmPNI deeper than the dermis\u201d are significantly and independently associated with poor prognosis after correction for other mPNI features and high-risk factors. One of these studies additionally identified \u201cinvolvement of \u22653 nerves\u201d as an independent and significant predictor of higher risk of local recurrence (HR, 2.17; 95% CI: 1.03\u20134.56; p = 0.04). Key Messages: Besides \u201cnerve diameter of \u22650.1 mm\u201d and \u201cdepth of mPNI involvement,\u201d \u201cinvolvement of multiple nerves\u201d was found to be an independent risk factor for poor prognosis and should also be considered for appropriate risk stratification. <\/jats:p>","DOI":"10.1159\/000542772","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T17:01:36Z","timestamp":1732726896000},"page":"203-209","source":"Crossref","is-referenced-by-count":8,"title":["Perineural Invasion for Risk Stratification in Cutaneous Squamous Cell Carcinoma: A Scoping Review"],"prefix":"10.1159","volume":"241","author":[{"given":"Emmy C.","family":"Cr\u00fcts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrthe M.G.","family":"Moermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrurgia","family":"Abdul Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty J.","family":"Nelemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-3050","authenticated-orcid":false,"given":"Klara","family":"Mosterd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.01.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3960"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21898"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.746"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.5326"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2456"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-09"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-20-00167"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13290"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221076110"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.017"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27458"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.11.046"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.040"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.3703"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01354.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.06.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01052.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.1984"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002923"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003085"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.1303"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01367.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/241\/2\/203\/4305450\/000542772.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/241\/2\/203\/4305450\/000542772.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:03:01Z","timestamp":1745420581000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,1]]},"published-print":{"date-parts":[[2025,3,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000542772","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.27917127","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}