{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:52:31Z","timestamp":1786639951499,"version":"build-2736575974"},"reference-count":27,"publisher":"S. Karger AG","issue":"8","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"abstract":"<jats:p>Introduction: Presence of macroscopic portal vein thrombosis (PVT) in patients with hepatocellular carcinoma (HCC) has been found to be a major poor prognosis characteristic. Aims: The aim of the study was to examine patients with PVT for their clinical characteristics and factors related to both PVT and survival. Methods: A large HCC database containing 1,094 patients with PVT and 2,513 patients without PVT was examined. Patients had routine baseline serum liver parameters and alpha-fetoprotein (AFP) levels measured, as well as radiological assessment of maximum tumor diameter (MTD), tumor number, presence of macroscopic PVT, plus survival. Results: The percent of patients with PVT increased with increase in both MTD and serum AFP levels and liver parameter levels were worse in patients with PVT than without it. A logistic regression model showed that the combination of MTD &gt;5 cm plus AFP &gt;100 IU\/mL plus albumin &lt;3.5 g\/dL had an odds ratio of 10.988 for the presence of PVT. Normal serum albumin levels significantly reduced the hazard ratio for death in a Cox proportional hazard model and were associated with decreased liver failure. Conclusion: Logistic regression showed the significance of MTD, AFP, and albumin in the presence of PVT, and the Cox model highlighted the importance of albumin levels in decreasing death. <\/jats:p>","DOI":"10.1159\/000542774","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T12:03:19Z","timestamp":1733745799000},"page":"667-676","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of HCC Patients with Portal Vein Thrombosis: Albumin and Survival"],"prefix":"10.1159","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-5077","authenticated-orcid":false,"given":"Brian","family":"Carr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezai","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i13.1330"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3120185"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-020-00489-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02845-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1317"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13567"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3922-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2020.12.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102458"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3120185"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2024.02.039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-52"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i47.7561"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102458"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21980"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60871-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15035163"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90177-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003162"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216935"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830301)51:5%3c863::aid-cncr2820510520%3e3.0.co;2-d"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249426"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33677"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i1.246"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1950-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13608"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000471807"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ocl\/article-pdf\/doi\/10.1159\/000542774\/4311354\/000542774.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000542774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:08:23Z","timestamp":1754410103000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000542774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000542774","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]}}}