{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:33:56Z","timestamp":1785818036092,"version":"3.56.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"abstract":"Introduction: We intended to compare the predictive value for all-cause and cardiovascular deaths between estimated glomerular filtration rate (eGFR) derived from the European Kidney Function Consortium (EKFC) cystatin C-based formula, the EKFC creatinine-based formula, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C- or creatinine-based formulas. Methods: Overall, 4,132 participants from the National Health and Nutrition Examination Survey between 1999 and 2002 were included, and death information was obtained through the National Death Index. To compare predictive accuracy between EKFC eGFR<sub>cys<\/sub> (EKFC cystatin C-based formula), CKD-EPI eGFR<sub>cys<\/sub> (CKD-EPI cystatin C-based formula), EKFC eGFR<sub>cr<\/sub> (EKFC creatinine-based formula), and CKD-EPI eGFR<sub>cr<\/sub> (CKD-EPI creatinine-based formula), we conducted time-dependent receiver operator characteristic (ROC) curves and reclassification analysis. Results: During a median follow-up of 17.4 years, a total of 1,987 all-cause and 530 cardiovascular deaths were confirmed. Restricted cubic splines analyses showed that reduced EKFC eGFR<sub>cys<\/sub> was linearly related to higher risks of all-cause and cardiovascular deaths (p for nonlinearity > 0.05). Time-dependent ROC curves suggested that EKFC eGFR<sub>cys<\/sub> exhibited higher predictive ability than CKD-EPI eGFR<sub>cys<\/sub>, EKFC eGFR<sub>cr<\/sub>, and CKD-EPI eGFR<sub>cr<\/sub> at 5-year and 10-year follow-ups. For 10-year all-cause deaths, EKFC eGFR<sub>cys<\/sub> yielded significant improvement over CKD-EPI eGFR<sub>cr<\/sub> (integrated discrimination improvement [IDI], 9.4%; net reclassification improvement [NRI], 39.7%). Similar improvement was observed in 10-year cardiovascular deaths when comparing EKFC eGFR<sub>cys<\/sub> to CKD-EPI eGFR<sub>cr<\/sub> (IDI, 6.7%; NRI, 45.1%). Conclusion: The EKFC eGFR<sub>cys<\/sub> outperformed CKD-EPI eGFR<sub>cys<\/sub>, EKFC eGFR<sub>cr<\/sub>, and CKD-EPI eGFR<sub>cr<\/sub> in predicting all-cause and cardiovascular deaths, providing the possibility to utilize EKFC eGFR<sub>cys<\/sub> in the stratification of death risk among the general US population. <\/jats:p>","DOI":"10.1159\/000542912","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:00:45Z","timestamp":1737115245000},"page":"267-278","source":"Crossref","is-referenced-by-count":1,"title":["The Superiority of European Kidney Function Consortium Cystatin C-Based Formula for Risk Stratification of All-Cause and Cardiovascular Deaths in US 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