{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:36:25Z","timestamp":1782398185679,"version":"3.54.5"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Bronchopulmonary dysplasia (BPD) is a common respiratory morbidity in preterm infants. The onset of pulmonary hypertension leads to worse respiratory outcomes. The contribution of left ventricular diastolic dysfunction in BPD-PH is well reported. We evaluated the serial left ventricular function and possible ventricular interdependence among BPD-PH. Methods: This is a single-center, prospective observational study. Infants &lt;28 weeks of gestation are included. Results: Eighty infants were enrolled. The incidence of BPD-PH was 23%. The BPD-PH group had a high incidence of hemodynamically significant ductus arteriosus (83% vs. 56%, p &lt; 0.018), longer oxygen days (96.2 \u00b1 68.1 vs. 59.35 \u00b1 52, p &lt; 0.008), and prolonged hospital stay (133.8 \u00b1 46 vs. 106.5 \u00b1 38 days, p &lt; 0.005). Serial tissue Doppler imaging showed prolonged left ventricle (LV) isovolumetric contraction time (IVCT) (31.05 \u00b1 3.3 vs. 26.8 \u00b1 4.4 ms, p &lt; 0.001) and myocardial performance index (MPI) (0.43 \u00b1 0.03 vs. 0.37 \u00b1 0.04, p &lt; 0.001) from 33 weeks. The changes in IVCT (35.9 \u00b1 6.7 vs. 27.9 \u00b1 4.5 ms, p &lt; 0.001), isovolumetric relaxation time (IVRT) (50 \u00b1 6.5 vs. 39.9 \u00b1 5.8 ms, p &lt; 0.001), and MPI (0.48 \u00b1 0.05 vs. 0.36 \u00b1 0.03, p &lt; 0.001) persisted at 36 weeks. The receiver operator characteristic curve showed LV MPI &gt;40 has 83% sensitivity and 65% specificity (AUC: 0.77, p &lt; 0.001) in the diagnosis of PH. The BPD-PH group had a higher LV E\/E\u2032 ratio (13.1 \u00b1 4.4 vs. 11.4 \u00b1 3.4, p &lt; 0.02). Pearson correlation test showed a moderate positive correlation between RV MPI and LV MPI (r = 0.585, p &lt; 0.001). Conclusions: Significant LV diastolic dysfunction was observed in BPD-PH. This is the first study to show biventricular strain and possible ventricular interdependence in BPD-PH. The prolonged LV IVRT and MPI may be a novel echocardiographic indicator of BPD-PH. <\/jats:p>","DOI":"10.1159\/000542980","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T17:01:26Z","timestamp":1733331686000},"page":"210-221","source":"Crossref","is-referenced-by-count":3,"title":["Characterizing the Role of Left Ventricular Indices and Biventricular Interaction in Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Extreme Prematurity"],"prefix":"10.1159","volume":"122","author":[{"given":"Krishna Revanna","family":"Gopagondanahalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanthan","family":"Sundararaghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng Hong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee 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