{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:36:42Z","timestamp":1783474602462,"version":"3.55.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"abstract":"<jats:p>Introduction: The SEWA cell line, which is derived from a virus-induced murine osteosarcoma (OS) ascites, was established in the 1980s from a serially transplanted male-derived tumor that was first published in 1961. It has been applied in about 50 studies but was never genetically characterized in detail; this study fills that gap. Methods: The SEWA cell line was analyzed for its chromosomal constitution using molecular cytogenetic approaches. Array comparative genomic hybridization was performed to characterize copy number alterations. Results: SEWA has a near-diploid karyotype without Y-chromosome material. The complex karyotype includes neocentrics and simple and complex rearrangements. Amplification of MYC oncogene was detected in two homogeneously staining regions on two different derivative chromosomes. Conclusion: An in silico translation of the obtained results to the human genome indicated that SEWA is suitable as a model for advanced human OS. <\/jats:p>","DOI":"10.1159\/000543063","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:07:24Z","timestamp":1733936844000},"page":"236-242","source":"Crossref","is-referenced-by-count":3,"title":["Cytogenomic Characterization of Murine Osteosarcoma Cell Line SEWA"],"prefix":"10.1159","volume":"164","author":[{"given":"Thomas","family":"Liehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rincic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328334581f"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00519-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10709"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20120"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1976.tb01573.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1977.tb01214.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333992"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/315345a0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174\/1574893611666160606164459"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2440"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870140103"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20239"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000130836"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1982.tb00720.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-6-44"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cgr\/article-pdf\/164\/5-6\/236\/4313115\/000543063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cgr\/article-pdf\/164\/5-6\/236\/4313115\/000543063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:05:49Z","timestamp":1745420749000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":15,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2025,2,11]]},"published-print":{"date-parts":[[2025,2,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000543063","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28004600","asserted-by":"subject"}]},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}