{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:12Z","timestamp":1745468592626,"version":"3.40.4"},"reference-count":44,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<jats:p>Introduction: This study was designed to test the hypothesis that coronary artery adaptations during the postpartum period are related to underlying reductions in endothelium-dependent relaxation and\/or augmented smooth muscle vasoconstrictor responsiveness. Methods: In vivo experiments were performed in control (nonpregnant) and postpartum swine 35\u201345 days of postdelivery, with isometric tension experiments performed in isolated coronary arteries from those animals. Results: Coronary artery rings demonstrated increases in active tension generation following incremental increases in passive stretch with no differences between groups. Endothelium-dependent relaxation to bradykinin was attenuated in arteries from postpartum swine versus control (p &lt; 0.005). Concentration-dependent contractions to the thromboxane A&lt;sub&gt;2&lt;\/sub&gt; mimetic U46619 (0.1 n&lt;sc&gt;m&lt;\/sc&gt;\u20131 \u00b5&lt;sc&gt;m&lt;\/sc&gt;) were shifted rightward (EC&lt;sub&gt;50&lt;\/sub&gt; 27 \u00b1 10 n&lt;sc&gt;m&lt;\/sc&gt; vs. 238 \u00b1 66 n&lt;sc&gt;m&lt;\/sc&gt;; p &lt; 0.01) in arteries from postpartum swine, with no changes in maximum contractile responses (p = 0.68). Intracoronary administration of U46619 (1 n&lt;sc&gt;m&lt;\/sc&gt;\u20131 \u00b5&lt;sc&gt;m&lt;\/sc&gt;) in open-chest swine decreased coronary blood flow \u223c45 \u00b1 3% in nonpregnant controls but had no effect on coronary blood flow in postpartum swine. Concentration-dependent contractions to KCl (5\u201390 m&lt;sc&gt;m&lt;\/sc&gt;) showed a rightward shift in arteries from postpartum swine (15.6 \u00b1 1.4 m&lt;sc&gt;m&lt;\/sc&gt; vs. 21.8 \u00b1 1.9 m&lt;sc&gt;m&lt;\/sc&gt;; p = 0.03), with no change in maximum response. Taken together, the postpartum period is associated with reduced endothelium-dependent relaxation and responsiveness to receptor-dependent and -independent vasoconstrictor stimuli. Conclusion: These findings indicate that chronic exposure of the coronary circulation to the pregnancy\/postpartum milieu results in functional adaptations in sensitivity to paracrine\/hormonal compounds that should be further explored. <\/jats:p>","DOI":"10.1159\/000543116","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:29:19Z","timestamp":1733938159000},"page":"78-87","source":"Crossref","is-referenced-by-count":0,"title":["Functional Adaptations in Coronary Reactivity following Healthy Pregnancy in Swine"],"prefix":"10.1159","volume":"62","author":[{"given":"Selina M.","family":"Tucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman I.","family":"Essajee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cooper 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