{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:15Z","timestamp":1745468595514,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Brain tumors are the most common solid tumors in pediatric oncology. Advances in the treatment of childhood brain tumors have led to increased survival; however, treatment-related morbidity remains high. The risk of developing overweight\/obesity or significant weight gain is commonly observed in children with a brain tumor often due to hypothalamic damage as a result of radiation therapy, surgery, or the tumor itself. This may be accompanied by endocrinopathies such as diabetes insipidus and central precocious puberty in survivors of a childhood brain tumor. Lifestyle intervention strategies are often ineffective in preventing and managing obesity. Patients have difficulty with adherence to dietary interventions due to prolonged exposure to high-dose steroids, compromised physical health due to the disease process, or limitations in mobility as a result of excessive weight gain or the sequelae of the tumor management. There are no effective interventions to prevent or manage obesity in this patient population. Case Presentation: We describe a case report of a 11-year-old female who underwent treatment for a ganglioglioma, WHO grade 1, and simultaneously experienced nearly 100-kg weight gain. After several unsuccessful attempts at lifestyle interventions, she was referred to endocrinology and prescribed a GLP-1 receptor agonist, semaglutide. Following treatment with semaglutide, significant weight loss was observed. Importantly, the patient reported enhanced quality of life and social activity. Conclusion: Anti-obesity medications are promising treatment options for this vulnerable patient group. Additional research is warranted to examine their use for the prevention and treatment of obesity in children with a brain tumor. <\/jats:p>","DOI":"10.1159\/000543178","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T17:00:55Z","timestamp":1734454855000},"page":"169-173","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacologic Management of Obesity in Neuro-Oncology: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Alexandra","family":"Lardieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidhu","family":"Thaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Citron-Zafrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Garvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stergios","family":"Zacharoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena J.","family":"Ladas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454213515548"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01765"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12224"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208601"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00087-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0997"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14224"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.5158"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.845937"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luad074"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1307889"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/169\/4316567\/000543178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/169\/4316567\/000543178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:07:07Z","timestamp":1745420827000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000543178","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28045448","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}