{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:52:08Z","timestamp":1761864728685,"version":"build-2065373602"},"reference-count":24,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"abstract":"<jats:p>Introduction: Hepatocellular carcinoma (HCC) holds high cancer mortality worldwide. Immunotherapy-based combination therapy, currently the first-line (1L) standard of care in advanced HCC, has shifted the treatment paradigm concerning both efficacy and safety outcomes. Data on immune-related adverse event surrogacy for efficacy outcomes are mixed. Case Report: We report the case of a 58-year-old male with chronic hepatitis C virus infection who presented with a voluminous shoulder HCC metastasis. Albeit an initial significant biochemical response with 1L sorafenib, progressive disease after 3 months plus a bleeding complication led to treatment discontinuation. Second-line nivolumab, although yielding a rapid clinical and biochemical response, was permanently ceased after 12 weeks due to a grade 3 immune-related hepatitis. Notably, 5 years post-treatment, the patient sustains a major biochemical and radiographic response. Discussion: This case highlights an unusual and sustained response to nivolumab treatment in HCC, following early treatment discontinuation due to severe hepatotoxicity. <\/jats:p>","DOI":"10.1159\/000543288","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T12:00:34Z","timestamp":1734696034000},"page":"306-313","source":"Crossref","is-referenced-by-count":1,"title":["Five-Year Sustained Response to Nivolumab in Hepatocellular Carcinoma following Serious Immune-Related Hepatitis"],"prefix":"10.1159","volume":"32","author":[{"given":"Jos\u00e9","family":"Le\u00e3o Mendes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Sofia","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Cabral","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Sardinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Boavida Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"da Luz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.01.033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12818"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.101567"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2100070"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.047"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy510"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v15.i4.689"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.100787"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.030"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30110711"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9454-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v11.i1.1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i44.16474"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.046"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00604-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2024.42.17_suppl.lba4008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1326097"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.001"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.03.050"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0726"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/pjg\/article-pdf\/doi\/10.1159\/000543288\/4318030\/000543288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:01:15Z","timestamp":1760371275000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,13]]},"published-print":{"date-parts":[[2025,10,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000543288","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28070810","asserted-by":"subject"}]},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"type":"print","value":"2341-4545"},{"type":"electronic","value":"2387-1954"}],"subject":[],"published":{"date-parts":[[2024,12,20]]}}}