{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:11:16Z","timestamp":1756635076716,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: In the ICARIA-MM trial, isatuximab plus pomalidomide-dexamethasone (Pd) significantly prolonged progression-free survival, compared with Pd alone, in patients with relapsed or refractory multiple myeloma (RRMM), including those with gain or amplification of chromosome 1q, region 2, band 1 (1q21+). Case Presentation: We describe a 62-year-old Japanese man with 1q21+ RRMM, previously treated with three lines of therapy, who had a rapid and durable response to isatuximab-Pd. After the first isatuximab-Pd cycle, he had a complete response or better, which was maintained throughout 54 cycles (4.25 years). Isatuximab-Pd was generally well tolerated. The only serious adverse event was grade 3 cataracts. Conclusion: Our case shows that isatuximab-Pd is capable of inducing an enduring response in a patient with 1q21+ RRMM. <\/jats:p>","DOI":"10.1159\/000543347","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T17:00:28Z","timestamp":1737219628000},"page":"262-270","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Effectiveness and Safety of Isatuximab in Combination with Pomalidomide and Dexamethasone in a Japanese Patient with Refractory Multiple Myeloma and 1q21 Amplification: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Takanori","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Sando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Sunami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000229"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00474-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009910"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1983427"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02614"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.hs9.0000970776.33983.01"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04917-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02134"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6619"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32556-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17499"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280660"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.04.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020256"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3302"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278888"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/262\/4325153\/000543347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/262\/4325153\/000543347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:08:04Z","timestamp":1745420884000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000543347","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28229777","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,1,17]]}}}