{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:39Z","timestamp":1788675459505,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glomerular Dis"],"abstract":"<jats:p>Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are FDA-approved for weight loss and are increasingly prescribed for patients with obesity and type 2 diabetes mellitus. Multiple studies have demonstrated desirable renal and cardiovascular benefits from these novel agents. So far, a few case reports of acute tubular injury and acute interstitial nephritis have been reported with GLP-1RA. Podocytopathies in association with semaglutide are rare. In this case report, we present a case of nephrotic syndrome that developed after exposure to semaglutide and propose potential pathophysiological mechanisms underlying this rare renal complication. Case Presentation: Herein, we report a novel case of a 43-year-old female who was evaluated in the nephrology clinic for abrupt onset of bilateral lower extremity edema and foamy urine, a few weeks after exposure to semaglutide. She was diagnosed with nephrotic syndrome and subsequently underwent a kidney biopsy, which revealed features suggestive of minimal change disease, along with coexistent thin basement membrane disease. Conclusion: GLP-1RAs have been increasingly prescribed due to their proven pleiotropic benefits, including improvements in albuminuria, glycemic control, weight loss, and cardioprotective effects. Despite the considerable benefits of GLP-1RAs, it is essential to recognize novel side effects. <\/jats:p>","DOI":"10.1159\/000543357","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T17:01:02Z","timestamp":1738342862000},"page":"103-108","source":"Crossref","is-referenced-by-count":4,"title":["Minimal Change Podocytopathy with Coexistent Thin Glomerular Basement Membrane following Exposure to Semaglutide"],"prefix":"10.1159","volume":"5","author":[{"given":"Karthik","family":"Kovvuru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha Rani","family":"Kanduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathon","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00367-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036418"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.03.030"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30313-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.10.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100561"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/aimcc.2023.1383"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1681\/asn.20233411s1247c"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(00)70033-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-699-TGBMNI"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/019131299281644"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/antib12010006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac021"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1471615"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000519008"}],"container-title":["Glomerular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/gdz\/article-pdf\/5\/1\/103\/4329971\/000543357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/gdz\/article-pdf\/5\/1\/103\/4329971\/000543357.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:08:08Z","timestamp":1745420888000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000543357","archive":["Portico"],"relation":{},"ISSN":["2673-3633"],"issn-type":[{"value":"2673-3633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}