{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:20Z","timestamp":1745468600330,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"abstract":"<jats:p>Introduction: Liquorice (Glycyrrhiza glabra) is a traditional herbal remedy with various pharmacological activities mainly used for digestive and respiratory ailments. GutGard\u00ae\u00a0is a flavonoid-rich, deglycyrrhizinated liquorice root extract and is standardized to glabridin (\u22653.5%\u2009w\/w), and others viz., glabrol, eicosanyl caffeate, docosyl caffeate, and total flavonoids (\u226510%\u2009w\/w) with glycyrrhizin (\u22643.0%\u2009w\/w)\u00a0 as glycyrrhizin causes electrolyte imbalance, hypertension, and water retention. Hence, the objective of the current study was to assess the efficacy, safety, and tolerability of GutGard\u00ae in managing gastroesophageal reflux (GER)-related symptoms when compared to placebo. Methods: It was a double-blind, parallel group, randomized, placebo-controlled trial with participants randomized in a 1:1 ratio to either the placebo group or GutGard\u00ae group. The duration of the interventions\/treatment was for 28 days and the follow-up visits were done at day 7, day 14, day 28, and day 35. A telephonic follow-up was also done on day 21. The primary outcome measures studied was the change in the Gastroesophageal Reflux Disease-Health-Related Quality of Life and the Gastroesophageal Reflux Disease Symptom Assessment Scale. Results: We screened a total of n = 296 participants and enrolled n = 200 participants and obtained written, informed consent from them. Participants in the GutGard\u00ae group reported a significantly better quality of life at the end of the intervention period (p = 0.014). They also reported earlier resolution of symptoms of GER as against the placebo group, especially the symptoms of heartburn (p = 0.017 on day 14 and p = 0.005 on day 28) and regurgitation (p = 0.025 on day 7, p = 0.029 on day 14, and p = 0.022 on day 28). Conclusions: The GutGard\u00ae group showed better and earlier resolution (within 2 weeks) of symptoms of GER as against the placebo group, especially heartburn and regurgitation. <\/jats:p>","DOI":"10.1159\/000543367","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T17:00:48Z","timestamp":1739206848000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of GutGard<sup>\u00ae<\/sup> in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial"],"prefix":"10.1159","author":[{"given":"Jeffrey Pradeep","family":"Raj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unnati","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh Namdeo","family":"Belhekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambika","family":"Mamde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Darak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwetal","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821232-5.00008-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03500-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.15226\/2374-6866\/4\/2\/00159"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/216970"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00768.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2007.00658.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010660425522"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5235-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1203236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.109.067843"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000549"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20163766"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1023\/a:1022812103923"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1300472"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00491.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.049"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.20-162"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0190"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/doi\/10.1159\/000543367\/4334196\/000543367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cmr\/article-pdf\/doi\/10.1159\/000543367\/4334196\/000543367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:08:15Z","timestamp":1745420895000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1159\/000543367","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28182167","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2025,2,10]]}}}