{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:10:22Z","timestamp":1785813022662,"version":"3.56.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>&lt;p&gt;Introduction: Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness. We investigated the association of early postnatal low-dose intravenous hydrocortisone used for the prevention of bronchopulmonary dysplasia (BPD) with ROP outcome among extremely preterm infants in a Swedish cohort. Methods: This retrospective cohort study included extremely preterm infants born before 28 weeks of gestational age (GA). Infants born September 2020\u2013August 2022, treated with low-dose intravenous hydrocortisone for prevention of BPD, were compared to untreated controls born September 2016\u2013August 2020. Hydrocortisone was administered postnatally with a dose of 0.5 mg\/kg twice daily for 7 days, followed by 0.5 mg\/kg per day for 3 days. Logistic regression, adjusted for GA, birth weight (BW), sex, and parenteral nutrition, was used in the primary analysis. For robustness, we performed 1:1 propensity score (PS) matching followed by logistic regression. Results: Of 245 preterm infants included, 65 were treated with low-dose hydrocortisone and 180 were untreated controls. Incidence of ROP treatment was reduced in the hydrocortisone group 18.5% (12\/65) versus controls 32.2% (58\/180), p = 0.038. One-to-one PS matching (n = 62 + 62) confirmed the reduced incidence of ROP treatment in the hydrocortisone-treated infants (odds ratio [OR]: 0.38, 95% confidence interval [95% CI]: 0.16\u20130.88, p = 0.025). After adjusting for GA, BW, sex, and parenteral nutrition \u226514 days, the reduced risk of ROP treatment after early hydrocortisone treatment persisted (OR: 0.31, 95% CI: 0.16\u20130.60, p = 0.0005). Conclusion: Early postnatal low-dose intravenous hydrocortisone used to prevent BPD may reduce the risk of ROP treatment among extremely preterm infants. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000543659","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T17:01:04Z","timestamp":1737478864000},"page":"329-338","source":"Crossref","is-referenced-by-count":3,"title":["Association between Early Postnatal Hydrocortisone and Retinopathy of Prematurity in Extremely Preterm Infants"],"prefix":"10.1159","volume":"122","author":[{"given":"Mariya","family":"Petrishka-Lozenska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Pivodic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Flisberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Hansen-Pupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-6410","authenticated-orcid":false,"given":"Lois E.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1244","authenticated-orcid":false,"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1891\/0730-0832.34.5.284"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15751"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.08.007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0943-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02673-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.09.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00415.2021"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00202-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.5653"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.2336"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2021.09.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2016.05.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13437"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000047059"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200531"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001145.pub5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001146.pub6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09948-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15470"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14049"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:03:40Z","timestamp":1748966620000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000543659","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28246844","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]}}}