{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:26:42Z","timestamp":1773966402743,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: The study investigated whether the disclosure of the chromosomal anomaly causing early pregnancy loss (EPL) favors the grief process and reduces psychological distress. Methods: Women experiencing EPL were invited to participate in the study at the time they were offered chorionic villi sampling (CVS) and karyotyping before uterine evacuation. They completed two online surveys: one a week after EPL and another a month later, after receiving cytogenetic results. The surveys measured anxiety (Hospital Anxiety and Depression Scale [HADS]), Beck Depression Inventory (BDI-II) cognitive depression factor items, post-traumatic stress disorder (Impact of the Event Scale-Revised [IES-R]), and rumination (Ruminative Responses Scale [RRS-10]). Participants were divided into groups based on the chromosomal anomaly found at CVS: A1 (autosomal trisomy), A2 (other anomalies), and B (no anomalies). Results: A significant score decline was observed in the four studied psychological scales assessing anxiety, depression, post-traumatic stress, and rumination, between the first and second survey. The proportion of women with a clinical score also demonstrated a significant decline, except for anxiety. When these changes were assessed after karyotypic group stratification, the group with other chromosomal anomalies (A2) showed the highest drop. This group also demonstrated a significantly higher depression score decline at multivariate regression analysis of the median. Conclusion: EPL significantly impacts women\u2019s mental health, with 19%\u201351% experiencing manifestations. Disclosing chromosomal anomalies may aid in psychological recovery, particularly in reducing clinical scores for depression. <\/jats:p>","DOI":"10.1159\/000543684","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T12:01:23Z","timestamp":1738843283000},"page":"377-387","source":"Crossref","is-referenced-by-count":2,"title":["Psychological Impact in Early Pregnancy Loss: The Effects of Disclosing the Causative Chromosomal Anomaly"],"prefix":"10.1159","volume":"52","author":[{"given":"Maria","family":"Borrell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Pauta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Mallorqu\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Ardiles-Ruesjas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Borobio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Illanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Matas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-4797","authenticated-orcid":false,"given":"Antoni","family":"Borrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000477707"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14795"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23641"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0884217504270714"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-021-01209-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1037\/\/0278-6133.20.2.112"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.10.016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7251.1708"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17515"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.01.039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02610-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6924.2008.00088.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1219990"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2003.07.010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2016.05.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.10.102"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.128.4.638"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)58144-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-8343(01)00124-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpsy.2024.104331"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000859"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/07481180050121471"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/fdt\/article-pdf\/doi\/10.1159\/000543684\/4332626\/000543684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:06:45Z","timestamp":1754410005000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000543684","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28358363","asserted-by":"subject"}]},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}