{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:14:28Z","timestamp":1749096868697,"version":"3.41.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"abstract":"<jats:p>Introduction: Adverse exposures in utero might cause adaptations of cardiovascular and metabolic organ development, predisposing individuals to an adverse cardio-metabolic risk profile from childhood onwards. We hypothesized that adaptations in metabolic pathways underlie these associations and examined associations of metabolite profiles at birth with childhood cardio-metabolic risk factors. Methods: The study included 763 mother-child pairs participating in an ongoing population-based prospective cohort study with an overall low disease risk. Cord blood serum concentrations of amino acids (AAs), nonesterified fatty acids, phospholipids and carnitines (Carn) were obtained using a liquid chromatography coupled with tandem mass-spectrometry. We measured android\/gynoid fat mass ratio, blood pressure, insulin, and lipid concentrations at the children\u2019s age of 5.9 (0.3) and 9.8 (0.9) years. Results: We did not observe associations of cord blood metabolites with systolic or diastolic blood pressure, insulin, triglycerides, and android\/gynoid fat mass ratio at both ages and cardio-metabolic risk clustering at age 10 years. Five short- and medium-chain Carn.a metabolites were positively associated with cardio-metabolic risk clustering at age 6 but did not survive more stringent confounder adjustment. Conclusion: No consistent associations between cord blood metabolites and cardiovascular risk factors at school age were observed. <\/jats:p>","DOI":"10.1159\/000543697","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T17:01:11Z","timestamp":1737997271000},"page":"171-179","source":"Crossref","is-referenced-by-count":0,"title":["Cord Blood Metabolite Profiles and Childhood Cardio-Metabolic Outcomes in a Population-Based Cohort"],"prefix":"10.1159","volume":"81","author":[{"given":"Christin","family":"Kaupper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Blaauwendraad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romy","family":"Gaillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold V.","family":"Koletzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S204017441500001X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14592"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(86)91340-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/004982599238047"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004801"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312236"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20901"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00087.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-020-01667-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.01.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/ac202602u"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1247-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbp.0000209082.09623.b4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214520750"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.148"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206074463"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055\/a-1263-0898"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11110739"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15809-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/846578"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000408"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56909-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1118-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0215"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.258897"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121169"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T16:02:54Z","timestamp":1749052974000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,4]]},"published-print":{"date-parts":[[2025,6,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000543697","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28269386","asserted-by":"subject"}]},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[2025,1,27]]}}}