{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:46:50Z","timestamp":1757612810779,"version":"3.44.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>&lt;p&gt;Background: Patients with chronic kidney disease undergoing maintenance hemodialysis (MHD) have an increased mortality. The CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc score, initially used for stroke prediction in atrial fibrillation, is relevant for various cardiovascular conditions. This study evaluates its effectiveness in predicting cardiovascular and all-cause mortality in MHD patients. Methods: Data are from the \u201cProspective Study of the Prognosis of Patients on Chronic Hemodialysis\u201d (PROHEMO) in Salvador, Brazil. Patients were divided by CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc scores: \u22642 and &gt;2. Cox regression estimated hazard ratios (HR) for death, both unadjusted and adjusted for confounders. We assessed the distribution of each score variable and its association with mortality. A modified CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc score was created due to the low percentage of patients over 75 (1.3%) and normotensive (4.6%). Results: A total of 237 patients (mean age 51.6 years; 57.0% male) were included in the study. There were 55 deaths, 21 from cardiovascular causes. For patients with a CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc score &gt;2, the unadjusted hazard of all-cause mortality was doubled (HR = 2.05; 95% CI: 1.20, 3.49) compared to those with a score \u22642, and the risk for cardiovascular deaths was more than threefold (HR = 3.53; 95% CI: 1.46, 8.54). These ratios remained consistent after adjusting for covariates. In the most comprehensive Cox model, the HR for all-cause mortality was 2.43 (95% CI: 1.38, 4.23) and for cardiovascular mortality was 3.52 (95% CI: 1.40, 8.84), similar to results from the modified CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc score. Conclusions: The results support the CHA&lt;sub&gt;2&lt;\/sub&gt;DS&lt;sub&gt;2&lt;\/sub&gt;-VASc score as a practical tool for identifying MHD patients at higher risk of mortality, especially from cardiovascular causes. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000543720","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T12:01:31Z","timestamp":1739275291000},"page":"493-504","source":"Crossref","is-referenced-by-count":1,"title":["CHA<sub>2<\/sub>DS<sub>2<\/sub>-VASc Score as a Predictor of Cardiovascular and All-Cause Mortality in a Prospective Cohort of Hemodialysis Patients of Predominantly African Ancestry: The PROHEMO"],"prefix":"10.1159","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-8754","authenticated-orcid":false,"given":"Gabriel Brayan","family":"Guti\u00e9rrez-Peredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-3485","authenticated-orcid":false,"given":"Andrea Jimena","family":"Guti\u00e9rrez-Peredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7072-749X","authenticated-orcid":false,"given":"Iris","family":"Monta\u00f1o-Castell\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-7268","authenticated-orcid":false,"given":"Marinho","family":"Marques da Silva Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Albuquerque da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Tereza","family":"Silva Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cacia","family":"Mendes Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Michell","family":"Correia Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Guimar\u00e3es Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-4206","authenticated-orcid":false,"given":"Gildete Barreto","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-683X","authenticated-orcid":false,"given":"Marcelo","family":"Barreto 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