{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:04:46Z","timestamp":1765213486334,"version":"3.46.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>Introduction: Patients with prostate cancer are at increased risk of cardiovascular events. A non-electrocardiogram gated CT scan of the thorax is part of the diagnostic workup, allowing for assessment of coronary calcifications. However, the prognostic impact of a coronary artery calcium score (CACS) obtained from such CT scans is uncertain. This study aimed to investigate the association between CACS and a combined endpoint of all-cause death, myocardial infarction, or stroke in patients with recently diagnosed prostate cancer. Methods: The primary analysis included patients (N = 571) with recently diagnosed prostate cancer and without known coronary artery disease undergoing prostate-specific membrane antigen positron emission tomography\/computed tomography (PSMA PET\/CT). Patients were stratified into four CACS groups. Cox proportional hazard models adjusted for risk factors were used to examine the association between CACS and the combined endpoint. Results: Patients were distributed in the four CACS groups as follows: CACS 0\u201310 (26%), 11\u201399 (21%), 100\u2013399 (24%), and \u2265400 (29%). An increased risk of the combined endpoint was found with increasing CACS. Compared with CACS 0\u201310, the hazard ratios for CACS 11\u201399, 100\u2013399 and \u2265400 were 0.95 (95% confidence interval [CI]: 0.37\u20132.42), 2.39 (95% CI: 1.13\u20135.09) and 3.14 (95% CI: 1.52\u20136.48), respectively. Only 53% of patients in the CACS \u2265400 group received statins. Conclusion: In patients with prostate cancer, assessment of a CACS from the initial PET\/CT scan allows for the identification of patients with a threefold higher risk of death, myocardial infarction, or stroke. Initiation of preventive statin treatment in these patients could reduce cardiovascular events.<\/jats:p>","DOI":"10.1159\/000543735","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T12:02:11Z","timestamp":1740484931000},"page":"650-659","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of Coronary Calcifications in Patients with Recently Diagnosed Prostate Cancer"],"prefix":"10.1159","volume":"150","author":[{"given":"Nina","family":"St\u00f8dkilde-J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas 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