{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:56:48Z","timestamp":1789073808279,"version":"build-2803163510"},"reference-count":38,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"abstract":"<jats:p>&lt;p&gt;Introduction: Whether the weight-loss plateau and its values differ in obesity with or without metabolic dysfunction-associated steatotic liver disease (MASLD) undergoing continuous lifestyle intervention remains unknown. We aimed to investigate this problem. Methods: This prospective observational cohort study included 305 patients with obesity and MASLD and 103 matched individuals with non-MASLD from January 2015 to April 2023, with a 12-month follow-up to monitor weight changes. Liver biochemistry, liver fat content with magnetic resonance imaging-based proton density fat fraction with Dixon sequence, and liver stiffness measurement via 2D-SWE were assessed at baseline and after 12 months. A validated weight trajectory regression model was applied to estimate the weight-loss plateau. Results: Individuals with MASLD and non-MASLD presented a similar timing of the weight plateau at 6 months, but patients with MASLD experienced less weight loss and maintained their weight plateaus longer compared to those with non-MASLD. Among patients with MASLD, a greater total weight loss (TWL) at 6 months was associated with better treatment response in hepatic steatosis and injury (all p &lt; 0.001). Further multivariate logistic analysis showed that the 6-month TWL was an independent predictor of subsequent improvements in hepatic steatosis (OR: 0.78, 95% CI: 0.72\u20130.84) and alanine aminotransferase levels (OR: 0.82, 95% CI: 0.76\u20130.90) at 12 months. Conclusion: Patients with MASLD experienced gradual weight loss followed by a prolonged plateau, with the maximum reduction observed at 6 months. The degree of 6-month weight loss was a valuable prognostic factor for the 12-month hepatic treatment outcomes. Strategies to overcome this plateau are essential for improving long-term treatment efficacy in MASLD. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000543818","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T12:02:08Z","timestamp":1741262528000},"page":"321-334","source":"Crossref","is-referenced-by-count":2,"title":["Weight-Loss Plateau during Lifestyle Intervention Predicts Treatment Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity"],"prefix":"10.1159","volume":"18","author":[{"given":"Ling","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00317-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00864-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21925"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000533586"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-023-06865-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000539371"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10094-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-017-0025-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111283"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.12.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.051"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.216416"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4729-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.061"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32358"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00501-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-23-393"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.09.034"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(78)90300-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.3513"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14818"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00408-y"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.08.012"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2013.08.019"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.02.008"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819879047"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.005"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20777"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155937"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14411"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.07.006"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06071-5"}],"container-title":["Obesity 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