{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:47:41Z","timestamp":1792176461934,"version":"4.4.0"},"reference-count":54,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"abstract":"<jats:p>Introduction: There is a lack of evidence to guide the choice between stereotactic radiosurgery (SRS) and neuroablative procedures for patients with medically refractory trigeminal neuralgia (TN). This meta-analysis aims to identify the outcomes of these interventions for TN. Methods: Studies identified through PubMed, MEDLINE, and Embase, were cohort studies or clinical trials, had \u226520 participants, and had a \u226512-month follow-up. All participants were \u226516 years old and had primary refractory TN. Studies reported outcomes using the Barrow Neurological Institute (BNI) scale. The Shapiro-Wilk test, Mann-Whitney U test, two-tailed T Test, Spearman\u2019s R, and ANCOVA were used to test statistical significance. Screening was done according to PRISMA guidelines. Bias assessment was according to the Newcastle-Ottawa Scale. Results: 3,288 patients from 37 studies were included (2,537 SRS, 751 neuroablative). Overall reporting of BNI I, II, III, IV, and V was 36.0%, 17.4%, 23.9%, 11.7%, and 10.9%, respectively, in the SRS cohort, and 63.6%, 10.4%, 11.1%, 7.3%, and 7.6%, respectively, in the neuroablative cohort (p &lt; 0.0001). Recurrence was 41.6% in the SRS cohort and 22.5% in the neuroablative cohort (p &lt; 0.001). The neuroablative cohort reported significantly higher rates of hypoesthesia (18.6% vs. 50.5%, p &lt; 0.0001), and minor (19.6% vs. 2.2%, p &lt; 0.0001) and major (3.4% vs. 1.3%, p &lt; 0.001) adverse effects compared to SRS. Conclusion: The findings suggest improved pain relief and reduced recurrence with neuroablative procedures compared to SRS, albeit conferring a higher rate of adverse effects. Neuroablative techniques may be more appropriate for patients with medically refractory TN who are unsuitable for microvascular decompression. <\/jats:p>","DOI":"10.1159\/000543859","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T17:02:33Z","timestamp":1738602153000},"page":"154-165","source":"Crossref","is-referenced-by-count":6,"title":["Stereotactic Radiosurgery versus Neuroablative Techniques for Medically Refractory Trigeminal Neuralgia: A Systematic Review and Meta-Analysis of Outcomes"],"prefix":"10.1159","volume":"103","author":[{"given":"Yash","family":"Akkara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolene Marie","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran 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