{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:24:09Z","timestamp":1771464249786,"version":"3.50.1"},"reference-count":33,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Objective: BRCA 1 and 2 mutation carriers are invited to follow intensive clinical and instrumental surveillance programs or are offered prophylactic ovarian surgery. These recommendations impact many aspects of their lives. The primary objective of this study was to assess the overall quality of life (HRQoL) before and after prophylactic bilateral salpingo-oophorectomy (BSO). Secondary objectives were investigating sexual health (SH) and fatigue severity state. Design: This was a single-center retrospective observational study. Setting: Women who underwent surgical treatment of bilateral salpingo-oophorectomy between 2018 and 2024 at \u201cDAI Materno Infantile\u201d of Azienda Ospedaliera Universitaria \u201cFederico II\u201d of Naples were included. Methods: These patients were tracked down to undergo specific questionnaires, such as \u201cGlobal Health Status (GHS) and Quality of Life Scale (QOL) (EORTC QLQ-C30),\u201d \u201cEORTC Sexual Health Questionnaire (QLQ-SH22),\u201d and \u201cFatigue Severity Scale (FSS),\u201d to evaluate their psychological, sexual, and general physical condition impact before the surgery, 3 and 6 months later. Results: The overall mean QoL score was 88.3 \u00b1 29.8 (mean \u00b1 standard deviation), and this score worsened when the surgery was performed at 3 months (p &lt; 0.0001) with a score of 51.7 \u00b1 30.7 and a mean difference (MD) of 36.6 points; instead, at 6 months, the overall mean QoL score was 73.1 \u00b1 24.3 with an MD of 21.4 points. FSS reported a score of 2.7 \u00b1 1.15 vs 4.2 \u00b1 1.59 (p &lt; 0.0001) vs 3.5 \u00b1 1.43 (p &lt; 0.0001), respectively, before and 3\u20136 months after surgery. EORTC QLQ-SH22 before and after treatment showed statistically significant changes in sexual satisfaction (p &lt; 0.0001). Conclusion: BSO may impact the quality of life regardless of the hormonal status of patients related to age or menopause, about both the functional evaluation and the psychological and emotional assessment report. The physical change related to the surgical procedure is associated with a mental shift that affects both the physical and sexual energy of our patients in the first 3 months postoperatively, with a slight improvement of these data at 6 months. <\/jats:p>","DOI":"10.1159\/000543869","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T12:01:45Z","timestamp":1738584105000},"page":"409-418","source":"Crossref","is-referenced-by-count":3,"title":["Impact on Global Health Status, Quality-Sexual Life and Chronic Fatigue State of Risk-Reducing Salpingo-Oophorectomy in Women Who Are BRCA1\/2 Mutation Carriers: Experience from a Third-Level Italian Center"],"prefix":"10.1159","volume":"90","author":[{"given":"Luigi","family":"Della 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