{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:45:03Z","timestamp":1770227103964,"version":"3.49.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Peritoneal mesothelioma is an extremely rare malignancy of the peritoneum. It has a poor prognosis, and the optimal systemic chemotherapy remains controversial. Here, we report two cases of peritoneal mesothelioma with long-term survival and complete response to carboplatin, pemetrexed, and bevacizumab chemotherapy. Case Presentation: Both patients were treated with six cycles of carboplatin (AUC 5), pemetrexed (750 mg\/m2), and bevacizumab (15 mg\/kg) followed by pemetrexed and bevacizumab as maintenance therapy. Partial response continued for over 6 years in case 1, and complete response was obtained in case 2. The patient in case 1 died after 7 years due to accidental pneumonia, and the patient in case 2 remained disease-free for over 2 years after initiation of chemotherapy. Conclusion: Little information is available regarding angiogenesis in malignant peritoneal mesothelioma, and carboplatin\/pemetrexed\/bevacizumab are off-labeled chemotherapy by Japanese healthcare system as yet. However, our experience suggested that combined chemotherapy with bevacizumab is a feasible option for systemic chemotherapy in cases of peritoneal mesothelioma. <\/jats:p>","DOI":"10.1159\/000543889","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:00:39Z","timestamp":1738256439000},"page":"278-285","source":"Crossref","is-referenced-by-count":1,"title":["Successful Response to First-Line Carboplatin, Pemetrexed, and Bevacizumab for Peritoneal Mesothelioma: Two Case Reports"],"prefix":"10.1159","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-0960","authenticated-orcid":false,"given":"Tomonobu","family":"Koizumi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-3928","authenticated-orcid":false,"given":"Shintaro","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nodoka","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-1038","authenticated-orcid":false,"given":"Takuro","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei-ichiro","family":"Eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040942"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21037\/dmr-22-19"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31817c73d6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01238-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13455"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2005.n.020"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.368"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00471-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32714-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.07.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13472"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S51916"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1340157"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-255916"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.08.01"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2019-105826"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08025-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0331"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33433"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3978-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00688-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.03.045"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21167"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/278\/4329560\/000543889.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/278\/4329560\/000543889.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:14:09Z","timestamp":1745421249000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000543889","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28309874","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]}}}