{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:40:03Z","timestamp":1748968803223,"version":"3.41.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>&lt;p&gt;Introduction: The prenatal shunt, ductus arteriosus (DA), typically closes during the cardio-pulmonary transition at birth. We evaluated maternal and neonatal factors associated with delayed closure of DA in term-born neonates. Methods: We conducted a retrospective cohort study that included full-term neonates from the prospective observational Copenhagen Baby Heart cohort study. We assessed the association between maternal and neonatal factors and delayed ductal closure. Results: We included 19,566 neonates, of whom 48% were female. Echocardiography was performed at a median age of 12 (IQR: 9\u201315) and 8 (IQR: 2\u201313) days for neonates with no DA and an open DA, respectively. Associations with delayed ductal closure included maternal obesity adjusted risk ratio = 2 (95% CI: 1\u20133.8), maternal hypothyroidism during pregnancy aRR = 2.02 (95% CI: 1.2\u20133.4), low Apgar 2.6 (95% CI: 1.2\u20136), high weight aRR = 1.81 (95% CI: 1.2\u20132.6), and length at birth aRR = 1.7 (95% CI: 1.1\u20132.6). Conclusion: The identified risk factors for delayed ductal closure in term-born neonates may help increase clinical attention and improve neonatal care. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000543915","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T17:04:14Z","timestamp":1739466254000},"page":"275-280","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and Neonatal Factors Associated with Delayed Closure of Ductus Arteriosus in Term-Born Neonates: Insights from the Copenhagen Baby Heart Cohort Study"],"prefix":"10.1159","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-6143","authenticated-orcid":false,"given":"Anton Friis","family":"Mariager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberte","family":"Hammeken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"Malham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheel Altaf","family":"Raja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-5703","authenticated-orcid":false,"given":"Anna","family":"Sellmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Navne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper Karmark","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe Lisbeth","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.05.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000529842"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025784"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.65.2.97"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.011541"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311143"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1404625"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0448-y"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab147"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.050"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28865"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3859388"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17164"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000543915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:03:46Z","timestamp":1748966626000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000543915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,3]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000543915","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28428881","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}