{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:12:13Z","timestamp":1783959133555,"version":"3.55.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"abstract":"<jats:p>Introduction: Histrelin acetate implant (HI) is an approved treatment option for children with central precocious puberty. Implant duration has been reported to surpass the recommended replacement interval of 1\u20132 years. Implant breakage is a known potential adverse effect during the extraction procedure. However, the bioactivity of the retained fragment has not been reported previously. Case Presentation: We present 3 cases of females with central precocious puberty, who received HI for pubertal suppression and experienced implant breakage during extraction. In 2 cases, the retained fragment suppressed pubertal hormone for 5 years. In the third case, the HI was left in place due to loss of follow-up, and the patient was amenorrheic for the next 6 years. In all 3 cases, menstruation occurred after the HI fragments were surgically removed. Conclusion: Our case series demonstrates that retained HI fragment can be bioactive for up to 5 years. If HI breakage occurs during removal, ultrasound localization and surgical extraction of the fragment should be performed.<\/jats:p>","DOI":"10.1159\/000544181","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T12:02:56Z","timestamp":1740657776000},"page":"642-646","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged Pubertal Suppression due to Retained Histrelin Implant in Three Children with Central Precocious Puberty"],"prefix":"10.1159","volume":"99","author":[{"given":"Ian","family":"Marpuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-3287","authenticated-orcid":false,"given":"Mitchell E.","family":"Geffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-0589","authenticated-orcid":false,"given":"Lily C.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000501336"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab189"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089\/trgh.2021.0130"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.05.033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2022-0557"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2020-0721"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.02.067"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2479"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.08.048"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.037"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2020.04.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.968485"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/hrp\/article-pdf\/doi\/10.1159\/000544181\/4344623\/000544181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:01:08Z","timestamp":1783958468000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,7,13]]},"published-print":{"date-parts":[[2026,7,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000544181","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]}}}