{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:26:30Z","timestamp":1766748390084,"version":"3.41.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Background: Functional dyspepsia (FD) is currently defined as episodic or recurrent epigastric pain or discomfort in the absence of organic diseases, lasting at least 4 weeks. FD is estimated to affect 7.2% of the worldwide population. Due to the underlying complex pathogenetic mechanisms, the therapy for FD is generally prescribed to treat the main symptoms experienced by the patient. Summary: Recently, a new herbal formulation has been proposed for treating FD. This plant-based preparation, called STW 5-II, is a fixed combination of six hydroethanolic herbal extracts from bitter candy tuft, peppermint leaf, chamomile flower, licorice root, caraway fruit, and melissa leaf. STW 5-II has been shown to be more effective than placebo in several controlled studies and clinical scenarios, allowing for its recent introduction into several European markets. Key Messages: This review aimed to describe the mechanisms of action of this herbal drug, its current and potential clinical indications, and to explore future perspectives for its use. <\/jats:p>","DOI":"10.1159\/000544695","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T17:01:10Z","timestamp":1740070870000},"page":"266-272","source":"Crossref","is-referenced-by-count":1,"title":["STW 5-II for Treatment of Functional Gastrointestinal Disorders: Mechanism and Clinical Efficacy"],"prefix":"10.1159","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":false,"given":"Antonio","family":"Tursi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-8996","authenticated-orcid":false,"given":"Beatrice","family":"Marinoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino 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