{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T16:41:52Z","timestamp":1750524112825,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Introduction: Ocrelizumab is a recombinant humanized anti-CD20 monoclonal antibody used to treat multiple sclerosis. Late-onset neutropenia, absolute neutrophil count &lt;1.5 \u00d7 109\/L that develops &gt;4 weeks after last drug administration, is a known adverse event associated with anti-CD20 monoclonal antibodies, including rituximab and ocrelizumab. Case Presentation: We present the case of a 27-year-old woman who developed severe late-onset neutropenia during her third trimester of pregnancy after treatment with ocrelizumab 6 months prior. Conclusion: Neurologists should be aware of this risk and consider additional hematologic monitoring for pregnant patients who received anti-CD20 therapy as therapies such as G-CSF are available to help prevent serious infections. <\/jats:p>","DOI":"10.1159\/000544749","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T17:20:07Z","timestamp":1743009607000},"page":"36-40","source":"Crossref","is-referenced-by-count":1,"title":["Severe Late-Onset Neutropenia in a Pregnant Patient with Multiple Sclerosis after Ocrelizumab"],"prefix":"10.1159","volume":"17","author":[{"given":"Casey J.","family":"Fealko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan N.","family":"Rolon-Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa J.L.","family":"Aitken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Gitlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14658"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2023.05.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104090"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.06.007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102155"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1941874420936438"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116603"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5299"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05357-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-023-01507-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105147"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2023.578066"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/20552173221085737"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.099101"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T16:01:36Z","timestamp":1745596896000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000544749","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28668479","asserted-by":"subject"}]},"ISSN":["1662-680X"],"issn-type":[{"type":"electronic","value":"1662-680X"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}