{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:13:19Z","timestamp":1787181199828,"version":"build-2736575974"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"abstract":"<jats:p>Introduction: Central centrifugal cicatricial alopecia (CCCA) is a progressive scarring alopecia. No disease activity scale exists, making assessment of therapeutic intervention difficult. This study introduces the CCCA Clinical Assessment Tool (C-CAT), a novel scale that quantifies symptom severity to facilitate tailored treatment and track disease progression. Methods: A retrospective review of patients with CCCA was assessed on degree of pruritus, erythema, pain, disease progression, and scalp resistance, each scored from 0 to 2, over the course of a minimum of 6 months of therapy. Results: Eighty-two patients were included. The average initial C-CAT score was 3.4, consistent with mild to moderate disease activity. After 6 months of treatment, 88% of patients had improvement in score, with 48% of all patients achieving remission. Intralesional kenalog injections and topical clobetasol were the most commonly used therapies. Patients required an average of 3.6 different treatments to achieve therapeutic response. Conclusion: The C-CAT provides a structured, quantitative method to assess CCCA severity, which facilitates tracking of disease improvement for the majority of patients with targeted therapy. While the subjective nature of some C-CAT components may lead to inter-rater variability, this tool promotes personalized, symptom-based treatment and supports clinicians and patients in understanding this complex condition.<\/jats:p>","DOI":"10.1159\/000544777","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:01:31Z","timestamp":1740052891000},"page":"309-315","source":"Crossref","is-referenced-by-count":1,"title":["Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool"],"prefix":"10.1159","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9169-5754","authenticated-orcid":false,"given":"Aasheen","family":"Qadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-4051","authenticated-orcid":false,"given":"Elizabeth","family":"Will","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-9682","authenticated-orcid":false,"given":"Crystal","family":"Aguh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14445"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.1257"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701188"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01540-08"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2023.09.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.054"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6673525"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0087-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.02.036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2013.12.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12043"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.5201"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1534734608320786"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S100816"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910761"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2005.00034.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.106208"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14524"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00740-w"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sad\/article-pdf\/doi\/10.1159\/000544777\/4341891\/000544777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:07:12Z","timestamp":1754410032000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000544777","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.22.24314172","asserted-by":"object"}]},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]}}}