{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:32:15Z","timestamp":1758479535774,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: EGFR-sensitive mutations bilateral diffuse lung adenocarcinoma (LUAD) complicated with acute respiratory distress syndrome (ARDS) is relatively rare. It is important to consider whether EGFR-TKI can be simultaneously received when treating with extracorporeal membrane oxygenation (ECMO) and anti-infective therapy in these patients, and what adverse events should be noted? Case Presentation: We report a case of EGFR 19 exon-deficient bilateral diffuse LUAD complicated with ARDS. When treated with ECMO and anti-infective therapy, the patient received oral osimertinib anti-tumor therapy simultaneously. The tumor receded, but eventually irreversible thrombocytopenia developed. Conclusion: For patients with severe lung cancer, anti-tumor efficacy and adverse events should be closely observed during anti-tumor therapy. <\/jats:p>","DOI":"10.1159\/000544788","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:00:54Z","timestamp":1739984454000},"page":"372-380","source":"Crossref","is-referenced-by-count":1,"title":["Thrombocytopenia in an EGFR 19 Exon-Deficient Bilateral Diffuse LUAD with ARDS Treated with ECMO and Osimertinib: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Donghai","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunliu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2021.102080"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08942-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246074"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.5007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.3223"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30508-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12852"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072212"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200427150-00007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(14)50011-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000001443"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2992-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-023-01328-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15844"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13534"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S384637"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01306-y"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005053"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/372\/4341396\/000544788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/cro\/article-pdf\/18\/1\/372\/4341396\/000544788.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:17:14Z","timestamp":1745421434000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000544788","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28451054","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,2,19]]}}}