{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:19Z","timestamp":1791895579481,"version":"4.3.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Excisional biopsy (EB) is the gold standard for large B-cell lymphomas (LBCLs) diagnosis. Based on recent advances in interventional radiology enabling accurate sampling with core needle biopsy (CNB), we evaluated efficacy and safety of CNB under imaging guidance for diagnosing LBCLs. Methods: At the Hematology and Pathology Units of the Federico II University Medical School of Naples (Italy), we retrospectively collected patients with lymphadenopathies suspected of lymphomas (during 2009\u20132022) of which the ultrasonography (US)-guided CNB lymph node samples were available. Subsequently, we investigated the accuracy and safety of US-guided CNB for LBCLs diagnosis. Results: Over a 12\u2010year period, 800 (superficial target, n = 560; deep\u2010seated target, n = 240) lymph node biopsies performed with 16\u2010gauge diameter modified Menghini needle under power\u2010Doppler ultrasonographic guidance have been evaluated in 800 patients. According to the reference standard, 220 were suffering from LBCLs (diffuse LBCL NOS [n = 196], and high-grade B-cell lymphoma with MYC and BCL2 rearrangements [n = 24]) subtypes, other malignancy subtypes (n = 510) and non-malignant findings (n = 70). For the series of LBCLs, the overall diagnostic accuracy of the micro\u2010histological sampling was 100% (95% confidence interval: 98%\u2013100%). The complications occurred with very low incidence and severity (grade \u22642). Conclusion: US-guided CNB is a less invasive method and can be considered an alternative to EB for LBCL diagnosis. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000544794","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:01:47Z","timestamp":1748260907000},"page":"241-251","source":"Crossref","is-referenced-by-count":9,"title":["Ultrasonography\u2010Guided Core\u2010Needle Biopsy for Newly Diagnosed Large B-Cell Lymphomas: Analysis on Diagnostic Efficacy and Safety in an Italian Retrospective Study"],"prefix":"10.1159","volume":"149","author":[{"given":"Marco","family":"Picardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Vincenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-5109","authenticated-orcid":false,"given":"Novella","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vigliar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Troncone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015520"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13545"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000516589"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007569"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP9ZAGKVJ8PDAX"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.11.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.171"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17371"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19273"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5942"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-2926-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3204"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2027612"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:02:09Z","timestamp":1779984129000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,28]]},"published-print":{"date-parts":[[2026,5,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000544794","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}