{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:15:18Z","timestamp":1782782118896,"version":"3.54.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<jats:p>Introduction: Light chain-mediated acute tubulointerstitial nephritis (LCTIN) is a rare and underrecognized renal manifestation of plasma cell dyscrasias, including multiple myeloma. It presents as a dense interstitial inflammatory infiltrate involving polyclonal lymphocytes and plasma cells, often mimicking other forms of tubulointerstitial nephritis and delaying the correct diagnosis. Case Presentation: A 46-year-old man was initially managed as having drug-induced acute interstitial nephritis due to NSAID use, responding only transiently to steroids. Upon relapse with worsening kidney function, hypercalcemia, and systemic symptoms, a second kidney biopsy demonstrated again an intense tubulointerstitial infiltrate and \u03ba-light chain proximal tubulopathy. Conclusion: This case illustrates that LCTIN can mimic relapsing interstitial nephritis. Early recognition and appropriate plasma cell-targeted therapy may significantly improve renal outcomes and guide clinical management. <\/jats:p>","DOI":"10.1159\/000544930","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:02:27Z","timestamp":1750939347000},"page":"170-176","source":"Crossref","is-referenced-by-count":1,"title":["A Relapsing Acute Tubulointerstitial Nephritis as an Expression of a Kappa Light Chain Multiple Myeloma: A Case Report"],"prefix":"10.1159","volume":"15","author":[{"given":"Andrea","family":"Angioi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Lepori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Floris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-9711","authenticated-orcid":false,"given":"Wisit","family":"Cheungpasitporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranca","family":"Cabiddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Pani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-165-LATINA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20796"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.328"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv222"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1078155213502569"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0077-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-875-RPSIAA"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.168"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009101089"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.117"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(96)80037-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v100.5.1817.h81702001817_1817_1827"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP41XCVBHEQCEL"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0437-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004391"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0493-OA"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000544930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T16:03:11Z","timestamp":1755014591000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000544930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000544930","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29412173","asserted-by":"subject"}]},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}