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Summary: Epidemiological evidence supports the antitumor effect of vitamin D mainly comes from the binding of its active metabolites and vitamin D receptor to play relevant biological functions. The meta-analysis generally reported that high vitamin D status was a protective factor for breast cancer. In addition, the relationship of vitamin D-related gene polymorphisms with the tumor and the relationship between vitamin D levels and tumor occurrence and risk have also attracted much attention. Key Messages: This paper reviews the research progress of vitamin D metabolism, potential anticancer mechanisms in the tumor microenvironment, and its relationship with the risk of different tumors, and explores the relationship between vitamin D-related gene polymorphisms and tumors, providing theoretical reference for primary prevention of future tumors. <\/jats:p>","DOI":"10.1159\/000545130","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T12:42:35Z","timestamp":1743511355000},"page":"448-456","source":"Crossref","is-referenced-by-count":1,"title":["Systematic Evaluation of Vitamin D and the Risk of Breast Cancer 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