{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:05:41Z","timestamp":1764090341350,"version":"3.45.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Changes in the number and functional capacity of T lymphocytes have been reported in chronic lymphocytic leukemia (CLL) patients. The aim of this study was to examine the prognostic significance of T-lymphocyte subgroups in CLL patients. Methods: Eighty-three previously untreated patients were retrospectively enrolled and flow cytometry results at diagnosis were examined. No difference was found in T-lymphocyte parameters according to age, gender, and disease stage. Results: The CD4 and CD7 percentages, CD4\/MBC (malignant B cell), CD8\/MBC, and CD7\/MBC values at diagnosis were significantly lower in patients with a progressive disease. T-lymphocyte percentages were significantly lower in deceased patients. In the univariate regression model, T-lymphocyte percentages, T-lymphocyte\/MBC ratios, HLA-DR+ percentage, Rai stage (intermediate + high risk), Binet stage (B+C), and beta-2 microglobulin level had significant effects on both progression-free survival (PFS) and overall survival (OS); treatment status (yes) had a significant effect only on PFS, while age at diagnosis (\u226565 years) had a significant effect only on OS. In the multivariate regression model, Rai stage, CD7\/MBC ratio, and treatment status (yes) had a significant effect on PFS; Rai stage and CD8\/MBC ratio had a significant effect on OS. Conclusion: Lower T-lymphocyte\/MBC ratios at diagnosis could be a marker for higher risk of CLL progression. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000545269","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:01:18Z","timestamp":1742216478000},"page":"618-627","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of T-Lymphocyte Subgroups at Diagnosis on the Prognosis of Chronic Lymphocytic Leukemia"],"prefix":"10.1159","volume":"148","author":[{"given":"Deniz","family":"Seyithanoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra Nazligul","family":"Sert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ozbalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metban","family":"Mastanzade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simge","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa N.","family":"Yenerel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199510193331606"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02788-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.3.1030"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v100.5.1795.h81702001795_1795_1801"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225326"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nature15395"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200012283432602"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.06.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30029-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0131-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0873-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2035"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16260"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v74.2.786.bloodjournal742786"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0250-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-11-2630"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.503820"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.2967"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9941"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15918"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0182"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/doi\/10.1159\/000545269\/4352635\/000545269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:00:53Z","timestamp":1764090053000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,11,25]]},"published-print":{"date-parts":[[2025,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000545269","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2025,3,17]]}}}