{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:33Z","timestamp":1787017953602,"version":"build-2736575974"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Heavy menstrual bleeding (HMB) poses a significant concern among adolescents and can arise from bleeding disorders. This study aimed to compare the clinical presentations and treatment of adolescents with HMB, distinguishing those with and without an underlying bleeding disorder. Methods: We conducted a retrospective analysis of adolescent patients presenting with HMB during 2014\u20132022 at specialized hematology-adolescent clinics in two tertiary referral hospitals in Israel. The study was approved by the Institutional Review Boards. Results: Seventy-seven adolescents underwent evaluation for HMB, and 19 of them were diagnosed with various bleeding disorders: platelet aggregation defects (5), immune thrombocytopenia (1), Glanzmann thrombasthenia (1), VWD type 1 (5), type 2 A (1), type 3 (3), and coagulation factor deficiencies (3). Notably, 38 patients (49%) were hospitalized. A higher bleeding score (BAT) significantly correlated with hospitalization and a lower hemoglobin level (p &lt; 0.001). We did not find any significant differences between adolescents with or without a bleeding disorder regarding age of presentation, time from menarche, BAT, hemoglobin, or platelet count. Conclusion: Our findings revealed the clinical presentations and treatments of adolescents with HMB are similar, regardless of the presence of a bleeding disorder. This emphasizes the importance of thorough evaluation in all adolescents presenting with HMB. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000545299","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T13:00:30Z","timestamp":1742043630000},"page":"682-689","source":"Crossref","is-referenced-by-count":2,"title":["Hematological Evaluation and Management of Menorrhagia in Adolescents: Lessons from Adolescent Heavy Menstrual Bleeding Clinics"],"prefix":"10.1159","volume":"148","author":[{"given":"Marganit","family":"Benish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi Shitrit","family":"Yarhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-2667","authenticated-orcid":false,"given":"Ivan","family":"Budnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chagit","family":"Klieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Harel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3494-9823","authenticated-orcid":false,"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf Arie","family":"Barg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-0336","authenticated-orcid":false,"given":"Sarina","family":"Levy-Mendelovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003411"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500342912"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.5040"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.05.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-848739"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S389241"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2022.0082"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2013.06.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14997"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7292(01)00357-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008002401"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12503"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13058"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/BLOODADVANCES.2020003265"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12256"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13883"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.225656"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018017418"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14974"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000249.pub2"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/doi\/10.1159\/000545299\/4352205\/000545299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:00:55Z","timestamp":1764090055000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,15]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,11,25]]},"published-print":{"date-parts":[[2025,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000545299","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,15]]}}}