{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:20:34Z","timestamp":1791951634060,"version":"4.3.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Background: There is a paucity of studies on the association between polycystic ovary syndrome (PCOS) and endometriosis and the occurrence of venous thromboembolism (VTE). Objective: Our study aimed to evaluate the association between PCOS, endometriosis, deep vein thrombosis (DVT), and pulmonary embolism (PE). Methods: This was a retrospective study of prospectively collected data using the Healthcare Cost and Utilization Project databases. We examined the association between PCOS and endometriosis with DVT and PE from a cohort of 12,814,970 female patients, aged 18\u201349 years, who were hospitalized between 2007 and 2014. Results: We observed increasing trends, with a relative increase of 140% (from 0.27% to 0.65%) for PCOS, 16% (from 0.43% to 0.50%) for DVT, and 39% (from 0.23% to 0.32%) for PE, whereas we observed a decline by 34% for endometriosis (from 0.85% to 0.56%). The unadjusted analysis showed an association between PCOS and VTE, which remained significant after adjustment for sociodemographic characteristics and comorbidities (OR = 2.16; 95% CI: 2.00\u20132.33 and OR = 2.44; 95% CI: 2.23\u20132.67 for DVT and PE, respectively). The association between endometriosis and VTE was age-dependent, with an increased risk of VTE among women 18\u201324 years whereas this risk was decreased among those 35 years and older. Conclusion: Our study indicates an association between PCOS and VTE and an age-dependent association between endometriosis and VTE.<\/jats:p>","DOI":"10.1159\/000545518","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T12:06:16Z","timestamp":1743681976000},"page":"603-610","source":"Crossref","is-referenced-by-count":9,"title":["Polycystic Ovary Syndrome, Endometriosis, and Venous Thromboembolism: A Population-Based Study"],"prefix":"10.1159","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-0073","authenticated-orcid":false,"given":"Hormoz","family":"Nassiri Kigloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Suarthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Togas","family":"Tulandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steeve","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.11.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.11.034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104292"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14519"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1220014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153822"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2254844"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14421"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-021-00813-w"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.120677"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34251"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.06.067"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2023.100132"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.03.041"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.178"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008799"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.03.021"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.04.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.11.019"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073789"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.06.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052734"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186957"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01584.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.07.014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118799195"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004969"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000542049"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-016-0078-1"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/goi\/article-pdf\/doi\/10.1159\/000545518\/4361814\/000545518.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:09:06Z","timestamp":1764608946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000545518","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28685315","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}