{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:21:52Z","timestamp":1777645312430,"version":"3.51.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>Introduction: Optic disc pit maculopathy (ODP-M) describes the variable intra- (IRF) and\/or subretinal fluid (SRF) accumulation complicating a congenital optic disc anomaly that is primarily observed in young adults. This study aimed to explore the morphological variance in ODP-M, in order to measure associations between demographic and functional characteristics and investigate the natural course of the disease. Methods: A single-centre, retrospective, observational study was performed. Subjects with ODP-M were identified through electronic notes review. Demographic characteristics, visual acuity, and anatomical features were analysed with respect to a predefined OCT-based sub-categorisation: type 1a: IRF only; type 1b: IRF + outer lamellar hole (OLH) +\/\u2212 SRF; type 2: SRF +\/\u2212 IRF (no OLH). Results: Fifty eyes (50 subjects) were sub-categorised according to fluid distribution into type 1a (34%), type 1b (28%), and type 2 ODP-M (38%). Those with type 2 were found to be significantly younger than those with types 1a\/b ODP-M (p &lt; 0.001) and accounted for 93% of cases occurring in subjects \u226420 years old. The presence of OLH (i.e., type 1b) was noted to be independently associated with worse final VA (p = 0.013) and higher likelihood of proceeding to surgery (p = 0.002). Conclusion: There appears to be an age-related variation in ODP-M morphology, indicating the possibility of separate pathoanatomical processes, with distinct clinical courses and potentially different optimal management strategies. Sub-categorisation of ODP-M according to the reported structural features may help guide management of this rare condition. <\/jats:p>","DOI":"10.1159\/000545664","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T16:18:08Z","timestamp":1743783488000},"page":"185-193","source":"Crossref","is-referenced-by-count":1,"title":["OCT-Derived Biomarkers in Optic Disc Pit Maculopathy Are Associated with Age, Visual Function, and Natural History"],"prefix":"10.1159","volume":"248","author":[{"given":"Edward","family":"Bloch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca C.","family":"Flores-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-0163","authenticated-orcid":false,"given":"Odysseas","family":"Georgiadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-2994","authenticated-orcid":false,"given":"Conor M.","family":"Ramsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndon","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(62)91180-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e31823f9abb"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(80)35278-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000658"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)91553-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31826f5234"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.05.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02429.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/112067210401400114"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s1091-8531(03)00008-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3129\/i09-215"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2002.127921"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-012-9314-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/icb.0000000000000815"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/meajo.MEAJO_181_19"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/2515841420950843"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130159008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(96)30568-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-007-9070-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.138184"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14730"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000230"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.22608\/APO.2018473"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000526023"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.01047"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000362263"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.05.010"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0562-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.142"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000576"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307128"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315075"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070090081044"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-13967"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1971.tb05939.x"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/oph\/article-pdf\/doi\/10.1159\/000545664\/4362532\/000545664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:04:14Z","timestamp":1751385854000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000545664","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}