{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T16:40:10Z","timestamp":1748018410898,"version":"3.41.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Cushing\u2019s syndrome (CS) due to ectopic adrenocorticotrophic hormone (ACTH) is rare and usually due to neuroendocrine neoplasia (NEN). Primary renal NEN is exceptionally rare but may be a cause of rapidly progressive CS. Case Presentation: A 51-year-old man presented with profound hypokalemia, cellulitis, and new-onset type 2 diabetes and hypertension with 1 month of muscle weakness, labile mood, and insomnia. CS due to ectopic ACTH production was confirmed. Biochemical control was achieved using a \u201cblock-and-replace\u201d regimen with dual blockade with ketoconazole and metyrapone and hydrocortisone replacement in addition to mineralocorticoid receptor blockade using spironolactone. CT and ultrasound demonstrated a 24 mm right renal lesion with features concerning for renal cell carcinoma. Right laparoscopic nephrectomy was performed. Histology demonstrated a WHO grade one NEN with ACTH staining. Conclusion: In CS, where the source of ectopic ACTH production is unable to be identified, a renal source should be considered. Diagnosis may be difficult as there are no reliable radiological characteristics to distinguish renal NENs from renal cell carcinomas, so a high degree of suspicion is required. <\/jats:p>","DOI":"10.1159\/000545734","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T16:01:39Z","timestamp":1744732899000},"page":"593-601","source":"Crossref","is-referenced-by-count":0,"title":["Cushing\u2019s Syndrome due to a Renal Neuroendocrine Tumor: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Vicka","family":"Poudyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne S.","family":"Elston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleen","family":"Nottingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Swarbrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880515)61:103.0.co;2-p"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0877"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.12.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0081"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luae255"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_38_17"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0320"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0464"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03596-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.109685"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0110"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00201"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1062729"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0380"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1204963"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.624251"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112512"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-1693-CTOTUT"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26029"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-20-0076"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004595"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242679"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0098"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3632"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182291a44"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb01765.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2484\/rcr.v9i2.923"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T16:02:19Z","timestamp":1748016139000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000545734","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28789724","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,4,14]]}}}