{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:29:06Z","timestamp":1771504146427,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>&lt;p&gt;Introduction: In contrast to high-flux dialysis (HFD) membranes, medium cut-off membranes (MCO) can potentially remove a wide range of middle molecules. Our study aimed to compare the clearance rate (CR) of fibroblast growth factor 23 (FGF-23) and other selected inflammatory cytokines between medium MCO and HFD membranes and investigate the intrasubject stability of these biomarkers. Methods: This prospective randomised case-crossover study recruited 20 adult patients who were randomised into two groups: group A: to start with 1 week of thrice-weekly dialysis using HFD membrane followed by a 3-week washout period and then 1 week of dialysis with an MCO membrane. Group B followed the reverse sequence. Blood samples were taken before and after each dialysis session for the analysis of the assessed biomarkers (FGF-23, interleukin-6 [IL-6], interleukin-18 [IL-18], high-sensitivity C-reactive protein [hsCRP], and dephosphorylated uncarboxylated matrix Gla protein [dp-ucMGP]). Wilcoxon signed rank and paired t tests were used for comparison between the membranes. One-way repeated measures ANOVA or Friedman tests were used for the intrasubject stability of the biomarkers. Results: The use of both MCO and HFD membranes resulted in a significant reduction of FGF-23 levels and other selected inflammatory cytokines. However, there was no significant difference in the CR: FGF-23 (0.31 vs. 0.23], p = 0.242), IL-6 (0.19 vs. 0.12, p = 0.215), IL-18 (\u22120.05 vs. \u22120.03, p = 0.704), dp-ucMGP (0.33 vs. 0.33, p = 0.903), and hsCRP (\u22120.05 vs. \u22120.08, p = 0.107). There was no significant intrasubject variability for all assessed biomarkers except in pre-dialysis high hsCRP levels when using HFD membrane. Conclusion: The use of both MCO and HFD membranes resulted in a significant reduction of FGF-23 levels and other selected inflammatory cytokines. However, the MCO membrane did not demonstrate a significant advantage over the HFD in the short term. There was no significant intrasubject variability for all assessed biomarkers apart from hsCRP. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000545745","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:01:39Z","timestamp":1745236899000},"page":"639-651","source":"Crossref","is-referenced-by-count":2,"title":["A Randomised Prospective Crossover Study on the Effects of Medium Cut-Off Membranes on FGF-23 and Inflammatory Mediators in Patients Receiving Regular Haemodialysis"],"prefix":"10.1159","volume":"54","author":[{"given":"Saif","family":"Al-Chalabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-4085","authenticated-orcid":false,"given":"Smeeta","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-6957","authenticated-orcid":false,"given":"Leon","family":"Schurgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Poulikakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000369817"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy179"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.632260"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.844506"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706130"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2174\/1570161115666170310092202"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/NDT\/GFH1054"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13121215"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10441015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv146"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1160\/th08-02-0087"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy373"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/srep18448"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13755"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1669-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz189"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/S12882-018-1127-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000150"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90311-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000531355"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000508061"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz189"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0169024"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/bpu\/article-pdf\/doi\/10.1159\/000545745\/4367099\/000545745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:03:18Z","timestamp":1764608598000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000545745","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}