{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:41:24Z","timestamp":1791654084446,"version":"4.3.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"abstract":"<jats:p>Introduction: Intrahepatic cholangiocarcinoma has demonstrated a consistently increasing incidence in recent years. In cases of unresectability, palliative chemotherapy often remains the only option, typically associated with a poor prognosis. Liver transplantation might be an option for otherwise unresectable intrahepatic cholangiocarcinoma. We aimed to conduct a prospective, non-randomized study to further explore the effects of living donor liver transplantation in the treatment of unresectable neoadjuvant-treated intrahepatic cholangiocarcinoma. Methods: Patients with unresectable intrahepatic cholangiocarcinoma having a stable disease or tumor regression after systemic chemotherapy without an extrahepatic tumor burden are suitable for study inclusion. For a local control of the tumor, an additional local ablative therapy in means of a selective internal radiotherapy is mandatory. The main concept of the surgical procedure is a liver transplantation using the left (segments II\u2013IV) or the right lobe (segments V\u2013VIII) of a living donor. In oncosurgical optimal conditions, a two-staged hepatectomy combined with the (initially) auxiliary transplantation of a left lateral lobe of a living donor is the possible. The patient recruitment will start in September 2024. Conclusion: The design of the LIVINCA study may provide patients with otherwise unresectable intrahepatic cholangiocarcinoma a chance for a curative treatment option. This procedure does not reduce the deceased donor organ supply because living donation is the primary treatment option in these patients. <\/jats:p>","DOI":"10.1159\/000545871","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T12:00:49Z","timestamp":1744632049000},"page":"514-523","source":"Crossref","is-referenced-by-count":2,"title":["Living Donor Liver Transplantation for Neoadjuvant-Treated, Unresectable Intrahepatic Cholangiocarcinoma (LIVINCA): Study Protocol for a One-Armed, Monocentric, Non-Randomized Trial"],"prefix":"10.1159","volume":"48","author":[{"given":"Laura","family":"Schwenk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Dondorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Rohland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin","family":"Ali-Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utz","family":"Settmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Rauchfu\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24955"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2026-1182"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0912-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003539"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5754\/hge10704"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30045-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001165"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83149-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16906"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.01.021"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61903-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12591"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.06.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.776863"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25737"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12659\/aot.895936"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28744"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.116"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.3702"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ort\/article-pdf\/doi\/10.1159\/000545871\/4365147\/000545871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:01:00Z","timestamp":1756828860000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,2]]},"published-print":{"date-parts":[[2025,9,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000545871","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28787258","asserted-by":"subject"}]},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]}}}