{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:24:18Z","timestamp":1745468658591,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"abstract":"<jats:p>Introduction\nHypereosinophilic Syndrome (HES) is an uncommon disorder characterized by persistent peripheral eosinophilia and involvement of different organs. It is rare in pediatric ages. \nCases Presentation\nWe present three pediatric patients diagnosed with HES exhibiting digestive symptoms. Clinical records, laboratory results, imaging studies, and treatment plans were systematically collected and analyzed. All patients underwent an extensive etiological investigation to exclude infectious, autoimmune, and tumoral causes. Treatment with corticosteroids resulted in symptomatic and analytical improvement in all patients.\nDiscussion\/ Conclusion\nThis case series highlights the complexity of pediatric HES presenting with digestive manifestations. The diverse clinical presentation underscores the importance of considering HES in the differential diagnosis of unexplained gastrointestinal symptoms in children. Diagnostic and treatment challenges demand a multidisciplinary approach. These insights enhance our knowledge of this rare condition, enlarging the limited literature on this subject in the pediatric population.\n\nIntrodu\u00e7\u00e3o\nA S\u00edndrome Hipereosinof\u00edlica (SHE) \u00e9 uma patologia pouco comum, caracterizada por eosinofilia perif\u00e9rica persistente e sinais de envolvimento de diferentes \u00f3rg\u00e3os. \u00c9 rara a ocorr\u00eancia em idade pedi\u00e1trica.\nApresenta\u00e7\u00e3o de casos\nApresentamos uma s\u00e9rie de tr\u00eas doentes pedi\u00e1tricos diagnosticados com SHE e que apresentavam sintomas digestivos. Foram colhidos e analisados os dados dos registos cl\u00ednicos, resultados laboratoriais, exames de imagem, e planos terap\u00eauticos. Todos os doentes foram submetidos a investiga\u00e7\u00e3o etiol\u00f3gica extensa para exclus\u00e3o de causas infecciosas, autoimunes e oncol\u00f3gicas. Todos os doentes apresentaram melhoria cl\u00ednica e anal\u00edtica com a corticoterapia.\nDiscuss\u00e3o\/Conclus\u00e3o\nEsta s\u00e9rie de casos enfatiza a complexidade da SHE com manifesta\u00e7\u00f5es digestivas em idade pedi\u00e1trica. As apresenta\u00e7\u00f5es cl\u00ednicas diversas e inespec\u00edficas refor\u00e7am a import\u00e2ncia de considerar a SHE no diagn\u00f3stico diferencial de crian\u00e7as com sintomas gastrointestinais inexplicados. Os desafios no diagn\u00f3stico e na terap\u00eautica exigem uma abordagem multidisciplinar. Com esta s\u00e9rie de casos, pretende-se contribuir para a literatura limitada dispon\u00edvel sobre esta patologia em idade pedi\u00e1trica.\n \n<\/jats:p>","DOI":"10.1159\/000545921","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T16:01:35Z","timestamp":1745337695000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["Hypereosinophilic syndrome presenting with digestive symptoms in pediatric patients: a portuguese tertiary hospital case series"],"prefix":"10.1159","author":[{"given":"Maria","family":"Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Catarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9u","family":"Espinheira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-147X","authenticated-orcid":false,"given":"Mariana","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Trindade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,4,21]]},"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:25:36Z","timestamp":1745421936000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000545921","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28815665","asserted-by":"subject"}]},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"type":"print","value":"2341-4545"},{"type":"electronic","value":"2387-1954"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}