{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:38:50Z","timestamp":1772602730703,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Introduction: Numerous imaging techniques, such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and line-field confocal OCT (LC-OCT), are available for skin evaluation. However, there remains a need for improved imaging methods to better understand tumor histology and enhance surgical margin detection. This study aimed to evaluate the quality of ex vivo LC-OCT images in cutaneous tumors, describe their morphological features, and correlate the findings with dermoscopy, in vivo RCM, and histology. Methods: A prospective study was conducted from June 2022 to July 2023, including patients aged \u226518 years with cutaneous tumors on the trunk or limbs. Clinical, dermoscopic, RCM, ex vivo LC-OCT, and histopathological images were collected from 10 tumors, including melanomas, seborrheic keratoses, basal cell carcinomas, and melanocytic nevi. Results: Ex vivo LC-OCT produced high-quality images equivalent to those from in vivo devices, enabling three-dimensional visualization of excised tumors. The images displayed cellular resolution with strong correlations to confocal microscopy and histology. Conclusion: Ex vivo LC-OCT shows promise for improving the evaluation of cutaneous tumors and may enhance dermato-oncological surgery, particularly in margin control. <\/jats:p>","DOI":"10.1159\/000545960","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:01:41Z","timestamp":1745236901000},"page":"230-239","source":"Crossref","is-referenced-by-count":1,"title":["Revolutionizing ex vivo Skin Imaging: 3D Characterization of Skin Tumors with ex vivo Line-Field Confocal Optical Coherence Tomography \u2013 A Pilot 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