{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:48:26Z","timestamp":1788961706281,"version":"build-2803163510"},"reference-count":26,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"abstract":"<jats:p>&lt;p&gt;Introduction: Cancer-associated venous thromboembolism (CAT) is a frequent and medical relevant problem. Guidelines recommend treatment with low molecular weight heparins (LMWH) or direct oral factor-Xa inhibitors as rivaroxaban for \u22653 months. Patient\u2019s preference and convenience is an important factor to guide treatment decision and to support treatment adherence. No data are available so far about patient-reported outcome in CAT. Methods: CONKO-011\/AIO-SUP-0115\/ass. was an open-label, prospective, multicenter German phase III trial for cancer patients with newly diagnosed venous thromboembolism (VTE) randomized to rivaroxaban (Riva) or site-specific LMWH. Primary endpoint was patient-reported treatment satisfaction, measured by the Anti-Clot Treatment Scale (ACTS). The 12-item ACTS Burdens scale (primary endpoint after 4 weeks) and the 3-item ACTS Benefits scale were analyzed at 4, 8 and 12 weeks. Secondary endpoints included recurrent VTE, major\/clinically relevant bleeding, safety, compliance, overall mortality at 3 and 6 months, quality of life measured by the Treatment Satisfaction Questionnaire for Medication II (TSQM II) and Spitzer Index. Results: Between 03\/2016 and 06\/2019, 247 (123 Riva\/124 LMWH) patients were randomized. Mean ACTS Burdens scores after 4 weeks were 52.8 versus 51.2 in favor of rivaroxaban (p = 0.019) with mean score differences ranging from 3.3 (week 8; p = 0.001) to 2.4 (week 12; p = 0.006). The treatment effect of ACTS burden was consistent over treatment time (p &lt; 0.001). More patients on LMWH requested to stop study treatment preterm (19.4% versus 11.1%). Conclusion: Oral treatment with rivaroxaban led to an improvement in patient-reported treatment satisfaction, particularly in reducing anticoagulation-related burden, resulting in less patient-requested treatment stops. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000545976","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:02:02Z","timestamp":1748260922000},"page":"685-695","source":"Crossref","is-referenced-by-count":4,"title":["CONKO-011\/AIO-SUP-0115\/ass.: Rivaroxaban Compared to Low Molecular Weight Heparin in Cancer Patients with Acute Venous Thromboembolism"],"prefix":"10.1159","volume":"48","author":[{"given":"Marianne","family":"Sinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lohneis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Roderburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"S\u00fcdhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Christoph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anett","family":"Krziwanie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Semrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Schlenska-Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Ettrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf Ulrich","family":"Trappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana Kaethe","family":"Striefler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-2737","authenticated-orcid":false,"given":"Uwe","family":"Pelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Dieter","family":"Wernecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Riess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007338"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25714"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-08-0615"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0119-2018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.09.039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.07.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2022.2087998"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/2279-042X.179560"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113572"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-10-120"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-12"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00066.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(81)90058-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2307\/2529712"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-03-0243"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2307\/2280779"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01289-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.8034"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.09.037"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15153"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2021.06.021"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000545976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:01:29Z","timestamp":1762794089000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000545976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000545976","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29143202","asserted-by":"subject"}]},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}