{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:49:08Z","timestamp":1788266948927,"version":"build-2803163510"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: Circulating tumor DNA (ctDNA) is a noninvasive liquid biopsy technique that can reflect the dynamic changes of tumors in real time. This study aims to clarify the predictive value of ctDNA detection for disease progression and metastasis risk in bladder cancer patients through systematic review and meta-analysis, providing a scientific basis for clinicians\u2019 individualized treatment decisions and risk stratification management for patients. Methods: Studies related to ctDNA in prognostic assessment of bladder cancer were screened by systematically searching PubMed, Cochrane Library, Web of Science, Willey library, CNKI, and other databases, and the search was from inception to December 2024, and the data were extracted and analyzed by Meta-analysis. Results: A total of 9 papers were included, and the results showed that ctDNA testing had a sensitivity of 0.68 (95% CI: 0.54\u20130.78), specificity of 0.76 (95% CI: 0.51\u20130.90), and an area under the curve of 0.75 (95% CI: 0.71\u20130.79), suggesting that it has a moderate level of diagnostic efficacy in the assessment of prognosis in bladder cancer. Positive likelihood ratio and negative likelihood ratio were 2.8 (95% CI: 1.24\u20136.35) and 0.43 (95% CI: 0.28\u20130.65), respectively, with a diagnostic odds ratio of 6.56 (95% CI: 2.12\u201320.33). Fagan\u2019s nomogram analysis showed that when the prior probability was 50%, the posttest probability increased to 74% for positive results and decreased to 30% for negative results. Deeks\u2019 funnel plot analysis indicated no significant publication bias (p = 0.24). A high level of heterogeneity (I2 &gt; 80%) was observed among the studies, which may stem from differences in detection techniques, disease stages of patients, and follow-up periods. Publication bias analysis revealed no significant bias (p = 0.24). Conclusion: ctDNA demonstrates some clinical application value in the prognostic assessment of bladder cancer and can assist in predicting patient recurrence and survival. However, its independent predictive efficacy is not enough to replace traditional assessment methods. Future studies should aim to optimize the detection technology, unify the study design, expand the sample size, and combine multi-omics data for joint analysis, in order to further improve its potential application in the prognostic assessment of bladder cancer. <\/jats:p>","DOI":"10.1159\/000546014","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:02:04Z","timestamp":1746187324000},"page":"399-411","source":"Crossref","is-referenced-by-count":3,"title":["The Value of Circulating Tumor DNA in the Prognostic Diagnosis of Bladder Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"109","author":[{"given":"Yu","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040594"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23111-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2018.0189"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.657483"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14432"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87770-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac083"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S173027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-20-1990"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.103951"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28830"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01180-w"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.802188"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0369"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020728"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1140"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316578"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr619"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143600"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103758"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2022.10.026"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29526"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04061-9"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T16:06:57Z","timestamp":1754410017000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2025,8,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000546014","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.28881788","asserted-by":"subject"}]},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]}}}