{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:10:18Z","timestamp":1761322218015,"version":"build-2065373602"},"reference-count":35,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<jats:p>Introduction: Sinonasal carcinomas (SNC) are rare, aggressive tumours with complex immunological aspects. Still, prognostic markers are missing. The study aimed to investigate the relationship between immune checkpoints \u2013 specifically programmed death-ligand 1 (PD-L1) and Indolamin-2,3-dioxygenase 1 (IDO-1) \u2013 and clinical parameters in SNC. Methods: In this monocentric study immunohistochemical analysis of the checkpoints PD-L1 and IDO-1 was carried out retrospectively in 85 SNC patients from 2004 to 2018. Tumour proportion score (TPS), combined positive score (CPS) and combined IDO-1 score classified the PD-L1 and IDO-1 expression. The study was conducted in a specialized tertiary care centre, indicating comprehensive multidisciplinary care with surgical, radiotherapeutic, and systemic treatment intervention. Results: Over a median observation period of 41 months, 52 squamous cell carcinomas (SCC, 61%) and 33 adenocarcinomas (AC, 39%) were included. A total of 31 patients (37%) were classified in UICC IV, 89.4% (n = 76) received a primary resection. Three-year progression-free survival (PFS)\/overall survival (OS) rates were 63.6%\/81.4% in SCC and 73.1%\/82.5% in AC, respectively. Sinonasal AC showed significantly more frequently negative PD-L1 expression and CPS &lt;1 compared to sinonasal SCC (p = 0.035, p = 0.002). Sinonasal SCC with TPS score &gt;50%, combined low IDO-1 score and high UICC stage showed significantly worse 3-year PFS and OS values (p &lt; 0.05). Conclusion: The study identifies PD-L1 and IDO-1 as possible prognostic factors for sinonasal SCC, but less so for sinonasal AC. A TPS score &gt;50% and combined low IDO-1 score correlate with shortened 3-year PFS and OS in sinonasal SCC. Immune checkpoints could, therefore, represent important target molecules for the prognosis assessment of sinonasal SCC.<\/jats:p>","DOI":"10.1159\/000546118","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:02:28Z","timestamp":1748001748000},"page":"98-107","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Role of PD-L1 and IDO-1 Expression in Sinonasal Carcinoma"],"prefix":"10.1159","volume":"87","author":[{"given":"Daria","family":"Rometsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"G\u00f6ttker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix 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