{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:26:17Z","timestamp":1755797177472,"version":"3.44.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"Introduction: Dialysate-to-patient chloride mass transfer may occur during continuous veno-venous hemodialysis (CVVHD) with regional citrate anticoagulation (RCA). However, additional RCA-related ultrafiltration (UF<sub>RCA<\/sub>) and plasma chloride shifts to the intracellular compartment may impact mass transfer evaluation to an unknown extent. Methods: In an ancillary prospective, single-center study, we evaluated chloride mass transfer J<sub>S,Cl<\/sub> of adult patients treated with CVVHD-RCA. Chloride concentrations were measured in the effluent, and at filter\u2019s inlet and outlet on the plasma side. J<sub>S,Cl<\/sub> was computed as the difference in chloride mass at the filter\u2019s inlet and outlet in each compartment (i.e., dialysate and plasma water). A positive J<sub>S,Cl<\/sub> indicated chloride mass removal from plasma water. We accounted for the additional ultrafiltration volume performed automatically by the CVVHD monitor to account for citrate and CaCl<sub>2<\/sub> administered volumes. Dialysate J<sub>S,Cl<\/sub> from the CLODICUS study (NCT04755491) were recomputed using this methodology. Results: We studied 10 patients with 18 observations. Dialysate J<sub>S,Cl<\/sub> was significantly lower than plasma J<sub>S,Cl<\/sub> (0.21 [0.07 to 0.24] vs. 0.31 [0.15 to 0.46] mmol.min\u22121, p < 0.05), indicative of chloride removal from plasma water not exclusively related to loss in the dialysate compartment. Chloride removal from plasma was significantly associated with greater decreases in plasma bicarbonate along the filter (p < 0.01). In the original CLODICUS study, UF<sub>RCA<\/sub> flow amounted to 207 (interquartile range: 172 to 217) mL.h\u22121, and the dialysate J<sub>S,Cl<\/sub> to 0.11 (\u22120.01 to 0.23) mmol.min\u22121. Increasing net ultrafiltration flow was associated with increasing dialysate J<sub>S,Cl<\/sub>. Conclusions: Plasma chloride mass removal during CVVHD-RCA is significantly greater than what is accounted for by dialysate-based loss, suggesting that plasma chloride is transferred to an intracellular compartment. Furthermore, to account for the online administration of citrate and CaCl<sub>2<\/sub> solutions, CVVHD-RCA applies additional ultrafiltration, which significantly contributes to chloride removal from plasma water. <\/jats:p>","DOI":"10.1159\/000546322","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:02:06Z","timestamp":1748433726000},"page":"404-412","source":"Crossref","is-referenced-by-count":0,"title":["Chloride Mass Transfers during Continuous Veno-Venous Hemodialysis with Regional Citrate Anticoagulation: Effects of Additional Ultrafiltration and Hamburger\u2019s Effect"],"prefix":"10.1159","volume":"54","author":[{"given":"Matthieu","family":"Chivot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-8939","authenticated-orcid":false,"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Deniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Bitker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03901.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13356"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000541059"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-358"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.245"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1489-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(69)90085-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086\/380208"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(78)90007-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00970.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2010.03.023"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1995.tb02277.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2010007500094"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/18.2.252"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-014-0041-8"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T16:01:04Z","timestamp":1755532864000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,8,18]]},"published-print":{"date-parts":[[2025,8,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000546322","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}