{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:32Z","timestamp":1787017952171,"version":"build-2736575974"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<jats:p>Introduction: QSOX1, a sulfhydryl oxidase involved in arterial remodelling, has recently emerged as a biomarker for preeclampsia and acute heart failure. This study sought the cardiovascular roles of Qsox1 in response to angiotensin II (AngII)-induced hypertension. Methods: With approval from an Animal Ethics Committee (CNREEA#9), two models were developed: Qsox1-invalidated adult male mice (Qsox1\u2212\/\u2212) mice (C57BL\/6J background) and a tamoxifen-inducible, vascular smooth muscle cell (VSMC)-specific Qsox1 knockout. Hypertension was induced via AngII minipumps and trans-aortic constriction, with assessments of cardiac function, vessel size, and VSMC phenotype. Results: Qsox1\u2212\/\u2212 at baseline had lower blood pressure and exhibited a synthetic\/immature VSMC phenotype in coronary arteries when compared to wild-type (WT). After 4 weeks of AngII infusion, Qsox1\u2212\/\u2212 mice showed acute heart failure, absent coronary media hypertrophy, and increased perivascular fibrosis compared to hypertensive WT controls (p &lt; 0.01). VSMC-specific Qsox1 knockout leading to the lack of Qsox1 in VSMC only impairs the phenotype of these cells without effecting cardiac function in response to AngII. Conclusion: These data implicate vascular Qsox1 in the adaptive mechanisms of VSMC to pressure overload such as the development of media hypertrophy.<\/jats:p>","DOI":"10.1159\/000546331","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T16:02:47Z","timestamp":1754064167000},"page":"289-303","source":"Crossref","is-referenced-by-count":4,"title":["Qsox1 Contributes to Vascular Remodelling in Response to Hypertension"],"prefix":"10.1159","volume":"62","author":[{"given":"Malha","family":"Sadoune","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Mourad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Luc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Ragot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Polidano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Cohen-Solal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvanna","family":"Dorrifourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane-Lise","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Caillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs135"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306088"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34126"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00030.Delbosc"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5440"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-011-9461-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238279"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0018"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3407"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs162"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2024.100826"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.04.014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07694"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.11.010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.190512"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.5.H2085"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1471459"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-019-00177-8"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:03:17Z","timestamp":1764954197000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,5]]},"published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000546331","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29771132","asserted-by":"subject"}]},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}