{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:44Z","timestamp":1783113944859,"version":"3.54.6"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: Erectile dysfunction (ED) is a common complication following radical prostatectomy (RP). Although phosphodiesterase type 5 inhibitors (PDE5is) are used for penile rehabilitation, their efficacy post-RP is limited. Low-intensity extracorporeal shockwave therapy (Li-ESWT) has emerged as a potential noninvasive treatment, promoting tissue regeneration. This study evaluates the effectiveness of Li-ESWT, with or without PDE5i, for post-RP ED. Methods: This prospective study included 104 patients who underwent nerve-sparing RP and received Li-ESWT. Patients were divided into two groups: group 1 received daily 5 mg tadalafil along with Li-ESWT, while group 2 received Li-ESWT alone. Erectile function was assessed using the International Index of Erectile Function (IIEF-5) at baseline, 6, 12, and 24 months postoperatively. Results: The preoperative mean IIEF-5 score was 15.7 \u00b1 4.7, with 54.8% of patients scoring below 17. Postoperatively, significant improvements in IIEF-5 scores were observed at 12 and 24 months in both groups compared to the 6th month. In patients with preoperative IIEF-5 &lt;17, group 1 showed significantly greater improvement in IIEF-5 scores compared to group 2 (p = 0.008). No significant difference was observed between the groups in patients with preoperative IIEF-5 \u226517 (p = 0.893). Conclusion: Li-ESWT is an effective treatment for ED following nerve-sparing RP, with or without PDE5i. In patients with mild-to-moderate or greater preoperative ED, the combination of PDE5i and Li-ESWT may provide additional benefits, whereas Li-ESWT alone appears sufficient for those with milder cases.<\/jats:p>","DOI":"10.1159\/000546359","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T12:00:55Z","timestamp":1747051255000},"page":"48-54","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Prospective Evaluation of Li-ESWT with or without PDE5 Inhibitors for Erectile Dysfunction following Nerve-Sparing Radical Prostatectomy"],"prefix":"10.1159","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-167X","authenticated-orcid":false,"given":"Rashad","family":"Sholan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-1468","authenticated-orcid":false,"given":"Rufat","family":"Aliyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9747-7210","authenticated-orcid":false,"given":"Seymur","family":"Karimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-1450","authenticated-orcid":false,"given":"Malahat","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2917-3039","authenticated-orcid":false,"given":"Anar","family":"Almazkhanli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2016.34.2.73"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14804"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfad023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.04.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1756287212470696"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2015.11.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2003.04373.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12135"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002440"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3171\/2016.4.SPINE15923"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.10.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.21037\/tau-19-888"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.047"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102775"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2017.02.004"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:02:19Z","timestamp":1770051739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,2]]},"published-print":{"date-parts":[[2026,2,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000546359","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,11]]}}}