{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:40:06Z","timestamp":1750437606829,"version":"3.41.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Adenoid cystic carcinoma (ACC), a rare, aggressive malignancy of secretory epithelia, is often present with nonspecific symptoms, delaying diagnosis. Case Presentation: A 67-year-old male reported 10 months of nasal obstruction, mouth breathing, and sleep disturbances. The initial evaluation for foreign body obstruction revealed septal deviation and low-density sinonasal tissue on CT. MRI identified a 7 \u00d7 4.5 \u00d7 7 cm heterogeneous lesion invading nasal structures, paranasal sinuses, and nasopharynx with diffusion restriction. Tru-cut biopsy confirmed ACC via cribriform, tubular, and solid basaloid cell patterns, pseudocystic spaces, biphasic ductal-myoepithelial cells, and perineural invasion. Immunohistochemistry (CK7, CD117, p63, S100) supported the diagnosis, with tumor-free margins and no metastases. Multimodal therapy (30 VMAT sessions, 4 cisplatin-vinorelbine cycles) improved symptoms. Conclusion: This case illustrates ACC\u2019s diagnostic complexity, requiring advanced imaging and histopathology to exclude mimics. Despite indolent early progression, ACC\u2019s neurotropic spread and late-stage detection demand aggressive treatment. While surgery with adjuvant radiotherapy remains standard, the absence of metastases here underscores its variable behavior. <\/jats:p>","DOI":"10.1159\/000546446","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T16:02:10Z","timestamp":1748448130000},"page":"809-816","source":"Crossref","is-referenced-by-count":0,"title":["Adenoid Cystic Carcinoma of the Sinonasal Cavity: A Case Report and Literature Review"],"prefix":"10.1159","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3173-1942","authenticated-orcid":false,"given":"Ahmad","family":"Al-Bitar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bishr A.","family":"Al-Abdulrazzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruba","family":"Alahmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26740"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N1729"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199809000-00006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-1529-ACCOTO"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2015.20.124.5927"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2022.102025"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-179"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215507"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.01.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/dj11110262"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2014.07.016"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0426-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.01.009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.06.016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041463"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041236"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1191218"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-012-0490-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812464020"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.6.541"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.11.005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3890-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23925"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69070"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30438-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31394-X"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.02.011"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.12.039"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:02:46Z","timestamp":1750435366000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546446","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29069957","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}