{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:36:59Z","timestamp":1785022619352,"version":"3.55.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: Some of the central nervous system malformations (CNSs) can be detected or suspected during the first trimester. Methods: Prospective observational study including singleton pregnancies, CRL between 60 and 82 mm and normal basic ultrasound examination. In the axial plane, we examined: lateral ventricles (LV), choroid plexus of LV (PCVL), PCVL\/VL ratio, insula, cerebellum, distance from Sylvian aqueduct to occipital bone, IV ventricle (IVV), and cisterna magna (CM) and in the sagittal plane, we assessed: 4 lines-3 spaces, brain stem (BS), fourth ventricle, IVV choroid plexus (PC), CM, distance from BS to occipital bone (BSOB) and BS\/BSOB ratio. Results: Ninety-two fetuses were included. The extended examination was successfully performed in 86 (93.5%) cases. The insula, LV and CPLV (axial planes) as well as all structures in the sagittal planes were assessed at 100%. The IVV, PC and CM (axial planes) were visualized at 90 (97.8%) fetuses. In 89 (96.7%) fetuses, the cerebellum was successfully evaluated, while in 88 (95.7%) cases, the tectum, aqueduct of Sylvius, and Ac-Oc distance were measured. Good intra- and interobserver concordance was observed for all parameters, as confirmed by Bland-Altman analyses. Advanced ultrasound increased the total examination time by 3 min compared to basic examination. Conclusions: Advanced first-trimester CNS assessment, including the incorporation of early markers to predict CNS abnormalities, is feasible with good intra- and interobserver agreement and minimal additional ultrasound scanning time.<\/jats:p>","DOI":"10.1159\/000546460","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:02:16Z","timestamp":1748433736000},"page":"547-560","source":"Crossref","is-referenced-by-count":1,"title":["Fetal Advanced Neurosonography in the First Trimester of Pregnancy"],"prefix":"10.1159","volume":"52","author":[{"given":"M\u00aa Angeles","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Albaiges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Illa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Prats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24888"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23616"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10088"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12302"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3899"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0797-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12914"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23149"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7552"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14883"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17445"}],"updated-by":[{"DOI":"10.1159\/000547612","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000}}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:02:53Z","timestamp":1764954173000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,5]]},"published-print":{"date-parts":[[2025,12,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000546460","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}